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Table 4 Association between LAP quartiles and increased risk of CKD in different participants

From: Association of lipid accumulation product with chronic kidney disease in Chinese community adults: a report from the REACTION study

Variable

LAP quartiles

P for trend

P for interaction

Q1

Q2

Q3

Q4

OR (95%C)

P-value

OR (95%CI)

P-value

OR (95%CI)

P-value

OR (95%CI)

P-value

Gender

     

0.511

 Men

1

1.269 (0.851–1.892)

0.243

0.912 (0.584–1.425)

0.687

1.472 (0.905–2.394)

0.120

0.211

 

 Women

1

0.982 (0.721–1.337)

0.908

0.989 (0.715–1.368)

0.947

1.462 (1.041–2.054)

0.029

0.006

 

Age, years

     

0.061

  < 60

1

1.098 (0.784–1.539)

0.586

1.077 (0.737–1.572)

0.702

1.622 (1.086–2.425)

0.018

0.050

 

  ≥ 60

1

1.071 (0.751–1.527)

0.705

0.927 (0.641–1.340)

0.686

1.427 (0.970–2.100)

0.071

0.014

 

BMI status

     

0.064

 Normal

1

1.096 (0.828–1.451)

0.522

0.914 (0.648–1.289)

0.609

1.288 (0.861–1.926)

0.218

0.492

 

 Overweight

1

1.110 (0.860–1.434)

0.422

0.993 (0.743–1.328)

0.963

1.473 (1.072–2.024)

0.017

0.002

 

 Obesity

1

1.510 (0.099–23.014)

0.767

4.444 (0.418–47.272)

0.216

2.061 (0.240–17.699)

0.510

0.125

 

Glucose metabolism status

     

0.636

 NGT

1

0.868 (0.624–1.208)

0.401

0.923 (0.633–1.345)

0.676

1.697 (1.117–2.577)

0.013

0.019

 

 Prediabetes

1

1.495 (0.904–2.472)

0.117

1.106 (0.650–1.884)

0.710

1.673 (0.943–2.969)

0.078

0.592

 

 T2DM

1

1.179 (0.662–2.101)

0.576

0.855 (0.492–1.485)

0.577

1.379 (0.798–2.381)

0.249

0.060

 

Blood pressure status

     

< 0.001

 Normal

1

1.061 (0.793–1.421)

0.689

0.932 (0.672–1.294)

0.675

1.568 (1.088–2.259)

0.016

0.065

 

 Hypertension

1

1.122 (0.717–1.756)

0.615

1.056 (0.667–1.671)

0.816

1.427 (0.908–2.242)

0.123

0.035

 

LDL-C

     

0.255

 Appropriate

1

1.177 (0.906–1.529)

0.222

1.052 (0.790–1.402)

0.727

1.505 (1.116–2.028)

0.007

0.014

 

 Borderline high

1

0.622 (0.265–1.461)

0.276

0.788 (0.354–1.753)

0.559

1.908 (0.787–4.622)

0.153

0.059

 

 High

1

0.326 (0.078–1.356)

0.123

0.207 (0.050–0.859)

0.030

0.891 (0.256–3.095)

0.856

0.747

 

CVD events

     

0.653

 No

1

1.066 (0.832–1.365)

0.613

0.920 (0.705–1.201)

0.539

1.476 (1.119–1.948)

0.006

0.007

 

 Yes

1

3.388 (0.685–16.748)

0.134

2.337 (0.683–8.005)

0.176

2.236 (0.447–11.198)

0.328

0.166

 

Current drinking status

     

0.640

 No

1

1.010 (0.757–1.350)

0.944

0.910 (0.671–1.234)

0.543

1.450 (1.051–2.000)

0.024

0.004

 

 Yes

1

1.238 (0.786–1.950)

0.357

1.070 (0.637–1.798)

0.799

1.471 (0.858–2.523)

0.161

0.590

 

Current smoking status

     

0.413

 No

1

1.082 (0.831–1.407)

0.559

1.019 (0.768–1.353)

0.895

1.455 (1.083–1.954)

0.013

0.004

 

 Yes

1

1.011 (0.525–1.946)

0.974

0.705 (0.355–1.400)

0.318

1.847 (0.848–4.026)

0.122

0.494

 
  1. Data are expressed as OR (95% CI) + P value, unless stated otherwise. Adjusted for sex, age, BMI, smoking, drinking, CVD events, SBP, DBP, LDL-C, prevalence of T2DM, and hypoglycemic drugs