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Table 5 Additive interaction between lifestyle-related factors and LDL-C/HDL-C on the risk of carotid plaques

From: Low−/high-density lipoprotein cholesterol ratio and carotid plaques in patients with coronary heart disease: a Chinese cohort study

Joint exposure

No. of participants

Carotid plaques

Lifestyle

LDL/HDL(> 3)

n

OR (95% CI)a

OR (95% CI)b

Intermediate/Favourable

NO

4522

3015

reference

reference

Unfavourable

NO

1776

1457

2.29(2.17–2.42)**

1.86(1.74–2.00)**

Intermediate/Favourable

Yes

2035

1574

1.71(1.62–1.79)**

1.63(1.54–1.72)**

Unfavourable

Yes

1093

943

3.15(2.92–3.39)**

2.59(2.37–2.82)**

  1. aModel 1: unadjusted;
  2. bModel 2: adjusted for age, sex, SBP, DBP, HbA1c;
  3. Compared with no carotid plaque, * P < 0.05, ** P < 0.01
  4. Measures of additive interaction for carotid plaques:
  5. Relative excess risk due to interaction (RERI): 2.777; 95% CI: 1.681–3.872;
  6. Attributable proportion due to interaction (AP): 0.209; 95% CI: 0.142–0.276;
  7. Synergy index (SI): 1.291; 95% CI: 1.178–1.416
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Lipids in Health and Disease

ISSN: 1476-511X