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Table 5 Effect size of GGT on NAFLD in prespecified and exploratory subgroups

From: Elevated gamma-glutamyl transferase has a non-linear association with incident non-alcoholic fatty liver disease in the non-obese Chinese population: a secondary retrospective study

Characteristic

No of participants

HR (95%CI)

P value

P for interacion

Age, years

0.5082

  < 30

2251

1.005 (0.999, 1.010)

0.1221

 

 30 to < 40

3549

1.010 (1.006, 1.014)

< 0.001

 

 40 to < 50

2700

1.011 (1.006, 1.016)

< 0.001

 

 50 to < 60

1570

1.009 (1.003, 1.015)

0.003

 

 60 to < 70

826

1.005 (0.996, 1.014)

0.272

 

  ≥ 70

1010

1.010 (1.003, 1.018)

0.009

 

Gender

0.2162

 Female

5395

1.008 (1.005–1.011)

< 0.001

 

 Male

6511

1.011 (1.008–1.013)

< 0.001

 

BMI (kg/m2)

0.1886

  < 18.5

942

1.038 (0.932, 1.155)

0.499

 

  ≥ 18.5, <  24

9377

1.013 (1.010, 1.015)

< 0.001

 

  ≥ 24

1587

1.009 (1.005, 1.012)

< 0.001

 

SBP (mmHg)

0.9399

  < 140

10,188

1.009 (1.007–1.012)

< 0.001

 

  ≥ 140

1718

1.010 (1.005–1.014)

< 0.001

 

DBP (mmHg)

0.7567

  < 90

10,941

1.010 (1.007–1.012)

< 0.001

 

  ≥ 90

965

1.010 (1.005–1.016)

< 0.001

 

HDL-c (mmol/L)

0.6828

 <1

1014

1.007 (1.001, 1.013)

0.0179

 

  ≥ 1

10,892

1.009 (1.006, 1.011)

< 0.001

 

ALT (U/L)

0.0011

  ≤ 40

11,314

1.012 (1.010, 1.015)

< 0.001

 

 >40

592

1.003 (0.998, 1.008)

0.1828

 

Cr (mmol/L)

0.0769

  < 82

5919

1.007 (1.003, 1.010)

< 0.001

 

  ≥ 82

5987

1.011 (1.008, 1.014)

< 0.001

 

UA (umol//L)

0.3937

 <420

10,962

1.010 (1.008, 1.012)

< 0.001

 

  ≥ 420

944

1.007 (1.002, 1.013)

0.007

 

FBG (mmol/L)

0.2557

 <6.1

11,074

1.010 (1.008, 1.013)

< 0.001

 

  ≥ 6.1

832

1.007 (1.002, 1.012)

0.009

 
  1. Note 1: Above model adjusted for age, gender, BMI, SBP, DBP,, TC, TG, HDL-C, LDL-C, ALT, AST, ALP, ALB, GLB, TB, DBIL, BUN, Cr, UA, FBG.
  2. Note 2: In each case, the model is not adjusted for the stratification variable