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Table 5 Effect size of GGT on NAFLD in prespecified and exploratory subgroups

From: Elevated gamma-glutamyl transferase has a non-linear association with incident non-alcoholic fatty liver disease in the non-obese Chinese population: a secondary retrospective study

Characteristic No of participants HR (95%CI) P value P for interacion
Age, years 0.5082
  < 30 2251 1.005 (0.999, 1.010) 0.1221  
 30 to < 40 3549 1.010 (1.006, 1.014) < 0.001  
 40 to < 50 2700 1.011 (1.006, 1.016) < 0.001  
 50 to < 60 1570 1.009 (1.003, 1.015) 0.003  
 60 to < 70 826 1.005 (0.996, 1.014) 0.272  
  ≥ 70 1010 1.010 (1.003, 1.018) 0.009  
Gender 0.2162
 Female 5395 1.008 (1.005–1.011) < 0.001  
 Male 6511 1.011 (1.008–1.013) < 0.001  
BMI (kg/m2) 0.1886
  < 18.5 942 1.038 (0.932, 1.155) 0.499  
  ≥ 18.5, <  24 9377 1.013 (1.010, 1.015) < 0.001  
  ≥ 24 1587 1.009 (1.005, 1.012) < 0.001  
SBP (mmHg) 0.9399
  < 140 10,188 1.009 (1.007–1.012) < 0.001  
  ≥ 140 1718 1.010 (1.005–1.014) < 0.001  
DBP (mmHg) 0.7567
  < 90 10,941 1.010 (1.007–1.012) < 0.001  
  ≥ 90 965 1.010 (1.005–1.016) < 0.001  
HDL-c (mmol/L) 0.6828
 <1 1014 1.007 (1.001, 1.013) 0.0179  
  ≥ 1 10,892 1.009 (1.006, 1.011) < 0.001  
ALT (U/L) 0.0011
  ≤ 40 11,314 1.012 (1.010, 1.015) < 0.001  
 >40 592 1.003 (0.998, 1.008) 0.1828  
Cr (mmol/L) 0.0769
  < 82 5919 1.007 (1.003, 1.010) < 0.001  
  ≥ 82 5987 1.011 (1.008, 1.014) < 0.001  
UA (umol//L) 0.3937
 <420 10,962 1.010 (1.008, 1.012) < 0.001  
  ≥ 420 944 1.007 (1.002, 1.013) 0.007  
FBG (mmol/L) 0.2557
 <6.1 11,074 1.010 (1.008, 1.013) < 0.001  
  ≥ 6.1 832 1.007 (1.002, 1.012) 0.009  
  1. Note 1: Above model adjusted for age, gender, BMI, SBP, DBP,, TC, TG, HDL-C, LDL-C, ALT, AST, ALP, ALB, GLB, TB, DBIL, BUN, Cr, UA, FBG.
  2. Note 2: In each case, the model is not adjusted for the stratification variable