Table 1 Definitions of relevant concomitant factors with extremely low HDL-C

Hypercholesterolemia

TC ≥200 mg/dL and/or LDL-C ≥130 mg/dL

Hypertriglyceridemia

TG ≥150 mg/dL

Systemic inflammation

hsCRP > 3.0 mg/L

Hypoalbuminemia

Serum albumin < 35 g/L

Hyperuricemia

Uric acid ≥ 417umol/L for male or uric acid ≥ 357umol/L for female

Renal dysfunction

eGFR < 60 ml/min/1.73m²

Anemia

Hemoglobin < 120 g/L for male or hemoglobin < 110 g/L for female

Low T3 syndrome

FT3 < 2. 63pmol/L with normal FT4 and TSH

Obese

BMI ≥ 28 kg/m²

Diabetes

Prior history or HbA1C ≥ 6.5 %

Current smoking

Smoking within 3 recent months

Alcohol consumption

Daily drinking of alcohol

Critical condition

MODS