Selective targeting of angiopoietin-like 3 (ANGPTL3) with vupanorsen for the treatment of patients with familial partial lipodystrophy (FPLD): results of a proof-of-concept study

Table 2 Demographics and baseline characteristics of patients

Demographics/baseline characteristics	Patient 01	Patient 02	Patient 07	Patient 08
Age (years)	43	41	38	47
Sex	Female	Male	Female	Female
Race	White	White	White	White
BMI (kg/m²)	24.7	33.5	33.6	30.9
FPLD diagnosis confirmed by genetics	LMNA R482Q	No	No	LMNA R584H
Family History of Abnormal and Similar Fat Distribution	Yes	Yes	Yes	Yes
Required a High Dose of Insulin	No	Yes	No	Yes
Acanthosis Nigricans	Yes	Yes	No	Yes
PCOS or PCOS-like symptoms	Yes	NA	Yes	Yes
History of Pancreatitis Associated with Hypertriglyceridemia	No	Yes	No	Yes
Non-alcoholic Fatty Liver Disease	Yes	Yes	Yes	Yes
Leptin (µg/L)	6.8	28.2	19.7	16.9
Adiponectin (mg/L)	3.3	0.8	5.2	4.5

BMI Body mass index, FPLD Familial partial lipodystrophy, PCOS Polycystic ovary syndrome

ISSN: 1476-511X