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Table 4 Changes in area under the curve from baseline during the mixed meal test in different metabolic parameters during the study

From: Selective targeting of angiopoietin-like 3 (ANGPTL3) with vupanorsen for the treatment of patients with familial partial lipodystrophy (FPLD): results of a proof-of-concept study

AUC

Baseline

Week 13

Week 27

Change from baseline to week 27 (%)

Triglycerides (mg/dL*min)

199120.0 (96813.0)

94270.0 (49145.2)

88022.5 (75031.1)

-60.1 (26.5)

Free Fatty Acids (mmol/L*min)

215.8 (55.2)

211.9 (75.5)

144.2 (65.4)

-32.1 (21.4)

Glucose

(mg/dL*min)a

76882.5 (16771.4)

65265.0 (11720.3)

64558.7 (11431.1)

-14.0 (5.2)

Insulin

(mIU/L*min)a

18790.1 (2499.7)

26972.7 (12877.3)

23440.0 (5329.6)

16.7 (19.1)

C peptide

(ng/mL*min)a

1761.5 (498.9)

1580.5 (890.9)

1484.1 (698.6)

-11.6 (16.6)

  1. Conversion factor for SI units: Triglyceride=0.0113 (mmol/L); glucose=0.0555 (mmol/L); insulin=6 (pmol/L); C peptide=0.33 (nmol/L)
  2. Data are presented as mean (SD). AUC area under the curve, SD standard deviation
  3. aOne patient (008) with unstable and difficult to control diabetes requiring treatment with high doses of U500 insulin was excluded from analysis of FPG and parameters related to circulating insulin
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Lipids in Health and Disease

ISSN: 1476-511X