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Table 1 Baseline characteristics of the concordance and discordance according to low or high TyG index and HOMA-IR categories

From: Discordance between the triglyceride glucose index and HOMA-IR in incident albuminuria: a cohort study from China

 

Total

TyG(−)&HOMA-IR(−)

TyG(+)&HOMA-IR(−)

TyG(−)&HOMA-IR(+)

TyG(+)&HOMA-IR(+)

P value

N

2446

1530

304

305

307

 

Age (year)

59.17 ± 8.94

58.64 ± 9.04

59.58 ± 8.62

60.64 ± 9.09

59.92 ± 8.40

0.0004

Male, n(%)

968 (39.6)

599 (39.2)

148 (48.7)

102 (33.4)

119 (38.8)

0.51

Current smoking, n(%)

488 (20.0)

311 (20.3)

84 (27.6)

40 (13.1)

53 (17.3)

0.05

Current drinking, n(%)

443 (18.1)

268 (17.5)

73 (24.0)

54 (17.7)

48 (15.6)

0.72

Physical activity (MET-h/wk)

23.10 (11.55–46.20)

23.10 (11.55–46.20)

23.10 (11.55–46.20)

23.10 (11.55–46.20)

23.10 (11.55–37.10)

0.005

Highschool education, n(%)

1949 (79.7)

1255 (82.0)

242 (79.6)

222 (72.8)

230 (74.9)

< 0.0001

SBP (mmHg)

135.98 ± 20.19

132.82 ± 19.91

138.04 ± 19.29

141.57 ± 19.78

143.99 ± 19.23

< 0.0001

DBP (mmHg)

78.36 ± 9.79

76.84 ± 9.70

79.64 ± 9.59

80.71 ± 9.27

82.23 ± 9.24

< 0.0001

PP (mmHg)

57.63 ± 16.38

55.98 ± 16.00

58.40 ± 15.63

60.86 ± 17.07

61.76 ± 17.00

< 0.0001

Height (cm)

159.93 ± 7.92

159.92 ± 7.75

160.53 ± 8.09

159.30 ± 7.81

159.99 ± 8.67

0.74

Weight (kg)

64.49 ± 10.59

62.17 ± 9.62

65.14 ± 9.58

69.92 ± 11.12

69.93 ± 11.58

< 0.0001

BMI (kg/m2)

25.17 ± 3.50

24.28 ± 3.19

25.20 ± 2.85

27.50 ± 3.54

27.29 ± 3.57

< 0.0001

FPG (mmol/L)

5.13 (4.70–5.82)

4.90 (4.60–5.30)

5.50 (5.00–6.20)

5.60 (5.00–6.50)

6.90 (5.70–9.00)

< 0.0001

Fasting insulin (μIU/ml)

7.00 (4.57–10.26)

5.57 (3.85–7.59)

6.81 (4.97–8.54)

14.04 (12.09–17.03)

12.95 (10.57–17.33)

< 0.0001

Post load glucose (mmol/L)

7.60 (6.10–11.30)

6.90 (5.60–8.40)

8.80 (7.00–13.20)

9.10 (7.00–14.55)

14.70 (10.70–19.25)

< 0.0001

HbA1c (%)

6.10 (5.80–6.60)

5.90 (5.70–6.20)

6.30 (5.80–6.90)

6.40 (6.00–7.10)

7.40 (6.50–8.90)

< 0.0001

HOMA-IR

1.65 (1.03–2.63)

1.25 (0.82–1.73)

1.79 (1.32–2.22)

3.45 (2.92–4.34)

4.01 (3.18–5.73)

< 0.0001

Total cholesterol (mmol/L)

5.15 ± 0.96

5.03 ± 0.89

5.42 ± 1.03

5.01 ± 0.98

5.63 ± 1.04

< 0.0001

Triglyceride (mmol/L)

1.41 (0.97–2.07)

1.16 (0.86–1.54)

2.89 (2.44–3.62)

1.35 (1.00–1.68)

2.65 (2.11–3.43)

< 0.0001

HDL cholesterol (mmol/L)

1.36 ± 0.31

1.42 ± 0.32

1.26 ± 0.25

1.29 ± 0.29

1.24 ± 0.20

< 0.0001

LDL cholesterol (mmol/L)

2.39 ± 0.68

2.35 ± 0.63

2.29 ± 0.74

2.53 ± 0.66

2.52 ± 0.80

< 0.0001

UACR (mg/g)

4.89 (2.45–9.23)

4.58 (2.32–8.40)

4.41 (2.42–9.47)

6.02 (2.92–11.92)

6.24 (2.93–12.13)

< 0.0001

eGFR (ml/min/1.73m2)

90.90 ± 12.75

91.25 ± 12.58

90.13 ± 12.90

89.66 ± 12.96

91.22 ± 13.20

0.31

TyG index

8.74 ± 0.68

8.40 ± 0.45

9.53 ± 0.32

8.68 ± 0.41

9.72 ± 0.52

< 0.0001

Medication use of ACEIs or ARBs, n(%)

74 (3.0)

33 (2.2)

8 (2.6)

13 (4.3)

20 (6.5)

< 0.0001

Diabetes, n(%)

860 (35.2)

310 (20.5)

138 (46.0)

167 (54.8)

245 (80.1)

< 0.0001

Hypertension, n(%)

1281 (52.4)

674 (45.1)

186 (61.6)

199 (66.3)

222 (72.6)

< 0.0001

History of MACEs, n(%)

213 (8.7)

112 (7.3)

37 (12.2)

28 (9.2)

36 (11.7)

0.007

MACEs at follow-up visit, n(%)

160 (6.5)

89 (5.8)

29 (9.5)

18 (5.9)

24 (7.8)

0.20

  1. Data are expressed as mean ± standard deviation, median (interquartile range) or as n (%). MET, metabolic equivalent task; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; PP, pulse pressure; FPG, fasting plasma glucose; HbA1c, glycated hemoglobin; LDL, low density lipoprotein; HDL, high density lipoprotein; UACR, urinary albumin-to-creatinine ratio; eGFR, estimated glomerular filtration rate; TyG, triglyceride-glucose; HOMA-IR, homeostasis model assessment of insulin resistance; ACEIs, angiotensin-converting enzyme inhibitors; ARBs, angiotensin receptor blockers