Race and sex differences in HDL peroxide content among American adults with and without type 2 diabetes

Flaherty, Shelby M.; Wood, Elizabeth K.; Ryff, Carol D.; Love, Gayle D.; Kelesidis, Theodoros; Berkowitz, Loni; Echeverría, Guadalupe; Rivera, Katherine; Rigotti, Attilio; Coe, Christopher L.

doi:10.1186/s12944-021-01608-4

Lipids in Health and Disease

Table 2 Means (S.D) for biomarker and clinical measures organized by race, sex, and diabetes status

From: Race and sex differences in HDL peroxide content among American adults with and without type 2 diabetes

	Men						Women
	Nondiabetic			Diabetic			Nondiabetic			Diabetic
Variable	White	Afr-Amer	p-value	White	Afr-Amer	p-value	White	Afr-Amer	p-value	White	Afr-Amer	p-value
n	629	85		114	32		692	160		98	93
Age (yrs.)	56 ± 13^b	50 ± 10^b	<.001	64 ± 12	56 ± 10	<.001	55 ± 12^b	49 ± 11^b	<.001	59 ± 11	54 ± 11	<.001
< 50	42 ± 6	42 ± 6	0.004^a	43 ± 6	45 ± 4	0.177^a	42 ± 5	41 ± 6	<.001^a	44 ± 3	42 ± 5	0.081^a
≥ 50	63 ± 8^b	58 ± 7	0.004^a	67 ± 9	60 ± 9	0.177^a	62 ± 9	59 ± 7		63 ± 8	60 ± 7	0.081^a
Adiposity and Glucoregulation
BMI (kg/m²)	29.1 ± 4.8^b	29.1 ± 6.7^b	<.001	31.7 ± 5.9	31.7 ± 6.7	<.001	28.0 ± 6.1^b	33.1 ± 8.1^b	<.001	33.7 ± 9.0	36.8 ± 9.8	<.001
Waist Circumference (cm)	102 ± 15^b	98 ± 17^b	<.001	111 ± 17	107 ± 18	<.001	89 ± 15^b	98 ± 16^b	<.001	104 ± 18	109 ± 22	<.001
HOMA-IR	3.5 ± 3.3^b	3.7 ± 3.8^b	<.001	9.4 ± 3.7	7.2 ± 6.9	<.001	2.7 ± 2.5^b	4.4 ± 4.5^b	<.001	7.2 ± 11.9	7.3 ± 6.9	0.286
HbA1c (%)	5.5 ± 0.42^b	5.6 ± 0.52^b	<.001	7.5 ± 1.4	7.7 ± 2.5	<.001	5.6 ± 0.4^b	5.7 ± 0.4^b	<.001	7.1 ± 1.3	8.0 ± 2.3	<.001
Blood Lipid Values
Total Cholesterol (mg/dL)	180 ± 37^b	188 ± 47^b	<.001	164 ± 39	169 ± 47	<.001	192 ± 37^b	180 ± 39	<.001	181 ± 42	187 ± 45	<.001
LDL-C (mg/dL)	102 ± 33^b	106 ± 45	<.001	87 ± 36	93 ± 40	<.001	105 ± 34^b	99 ± 33	<.001	97 ± 40	103 ± 37	<.001
Triglycerides (mg/dL)	132 ± 71^b	118 ± 74	<.001	168 ± 89	128 ± 86	<.001	109 ± 62^b	94 ± 56^b	<.001	147 ± 84	126 ± 72	<.001
non-HDL-C (mg/dL)	130 ± 38^b	130 ± 51	<.001	121 ± 40	119 ± 46	<.001	128 ± 39	118 ± 37	<.001	127 ± 45	128 ± 44	<.001
HDL-C (mg/dL)	51 ± 16^b	58 ± 21^b	<.001	42 ± 14	50 ± 14	<.001	65 ± 19^b	62 ± 17	<.001	54 ± 18	59 ± 20	<.001
HDLperox	13.2 ± 6^b	10.4 ± 6	<.001	14.9 ± 6	12.1 ± 5	<.001	10.1 ± 5^b	9.7 ± 4	<.001	11.7 ± 5	10.5 ± 5	<.001

^achi-square test ^bt-test comparing race and diabetes status Significance shown by bolded p value

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