|
Protein
|
Names*
|
Endocannabinoid system
|
Endocannabinoidome
|
|---|
|
Lipid signalling mediators
|
|---|
|
NAEs
|
2-MAGs
|
NAEs
|
2-MAGs
|
NAAs
|
|---|
|
Enzymes
|
|
Anabolic
|
NAPE-PLD
|
AEA
|
–
|
PEA, OEA, LEA and others
|
–
|
–
|
|
ABHD4
|
AEA
|
–
|
PEA, OEA, LEA and others
|
–
|
–
|
|
GDE1
|
AEA
|
–
|
PEA, OEA, LEA and others
|
–
|
–
|
|
DAGL-⍺/β
|
–
|
2-AG
|
PEA, OEA, LEA and others
|
2-OG, 2-LG and others
|
–
|
|
Catabolic
|
FAAH
|
AEA
|
2-AG
|
PEA, OEA, LEA, DHEA
|
–
|
NOleG, NAraG
|
|
MAGL
|
–
|
2-AG
|
–
|
2-OG, 2-LG and others
|
–
|
|
ABHD6
|
–
|
2-AG
|
–
|
2-OG, 2-LG and others
|
–
|
|
COX-2
|
AEA
|
2-AG
|
–
|
–
|
C20:4n6 amides
|
|
ABHD12
|
–
|
2-AG
|
–
|
2-OG, 2-LG and others
|
–
|
|
Cannabinoid receptors
|
CB1
|
AEA
|
2-AG
|
–
|
–
|
–
|
|
CB2
|
AEA
|
2-AG
|
EPEA, DHEA
|
–
|
–
|
|
G protein-coupled receptors
|
GPR6
|
–
|
–
|
–
|
–
|
NAraG
|
|
GPR18
|
–
|
–
|
–
|
–
|
NAraG
|
|
GPR55
|
AEA
|
2-AG
|
PEA
|
–
|
–
|
|
GPR110
|
–
|
–
|
DHEA
|
–
|
–
|
|
GPR119
|
–
|
–
|
OEA, LEA
|
2-OG, 2-LG
|
–
|
|
Peroxisome proliferator-activated receptors
|
PPAR-⍺
|
–
|
–
|
PEA, OEA
|
2-PG
|
NOleA, NOleG
|
|
PPAR-γ
|
AEA, DHEA
|
–
|
–
|
–
|
–
|
|
Transient receptor potential channels
|
TRPV1
|
AEA
|
2-AG
|
OEA, LEA, DHEA
|
2-OG, 2-LG
|
NATaus
|
|
TRPV2
|
–
|
–
|
OEA, LEA, as antagonists
|
–
|
–
|
|
TRPV3
|
–
|
–
|
–
|
–
|
–
|
|
TRPV4
|
–
|
–
|
–
|
–
|
NATaus
|
|
TRPA1
|
–
|
–
|
–
|
–
|
–
|
|
TRPM8
|
AEA, as antagonist
|
2-AG, as antagonist
|
–
|
–
|
–
|
- Note (alphabetical order): *Protein names are ordered in the rank of importance. 2-AG, 2-arachidonoylglycerol; 2-LG, 2-linoleoylglycerol; 2-MAGs, 2-monoacylglycerols; 2-OG, 2-oleoylglycerol; 2-PG, 2-palmitoylglycerol; ABHD4, 6, 12, ⍺/β-hydrolases 4, 6, 12; AEA, arachidonoylethanolamide; CB1, 2, cannabinoid receptors1, 2; COX-2, cyclooxygenase-2; DAGL-⍺/β, diacylglycerol lipase-⍺/β; DHEA, docosahexaenoylethanolamide; EPEA, eicosapentaenoylethanolamide; FAAH, fatty acid amide hydrolase; GDE1, glycerophosphodiester phosphodiesterase 1; GPR6, 18, 55, 110, 119, G protein-coupled receptors6, 18, 55, 110, 119; LEA, linoleoylethanolamide; MAGL, monoacylglycerol lipase; NAAs, N-acyl-amino acids; NAEs, N-acyl-ethanolamines; NAPE-PLD, N-acyl phosphatidylethanolamine phospholipase D; NAraG, N-arachidonoyl-glycine; NATaus, N-acyl taurines; NOleA, N-oleoyl-alanine; NOleG, N-oleyl-glycine; OEA, oleoylethanolamide; PEA, palmitoylethanolamide; PPAR-⍺/γ, peroxisome proliferator-activated receptors-alpha/gamma; TRPA1, transient receptor potential ankyrin 1; TRPM8, transient receptor potential melastatin 8; TRPV1, 2, 3, 4; transient receptor potential vanilloid 1, 2, 3, 4.
