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Table 1 Lipid mediators and their subsequent action on enzymes and receptors involved in the endocannabinoid system and endocannabinoidome.

From: (Wh)olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N)utrition (WHEN) to Curb Obesity and Related Disorders

Protein Names* Endocannabinoid system Endocannabinoidome
Lipid signalling mediators
NAEs 2-MAGs NAEs 2-MAGs NAAs
Enzymes
 Anabolic NAPE-PLD AEA PEA, OEA, LEA and others
ABHD4 AEA PEA, OEA, LEA and others
GDE1 AEA PEA, OEA, LEA and others
DAGL-⍺/β 2-AG PEA, OEA, LEA and others 2-OG, 2-LG and others
 Catabolic FAAH AEA 2-AG PEA, OEA, LEA, DHEA NOleG, NAraG
MAGL 2-AG 2-OG, 2-LG and others
ABHD6 2-AG 2-OG, 2-LG and others
COX-2 AEA 2-AG C20:4n6 amides
ABHD12 2-AG 2-OG, 2-LG and others
Cannabinoid receptors CB1 AEA 2-AG
CB2 AEA 2-AG EPEA, DHEA
G protein-coupled receptors GPR6 NAraG
GPR18 NAraG
GPR55 AEA 2-AG PEA
GPR110 DHEA
GPR119 OEA, LEA 2-OG, 2-LG
Peroxisome proliferator-activated receptors PPAR-⍺ PEA, OEA 2-PG NOleA, NOleG
PPAR-γ AEA, DHEA
Transient receptor potential channels TRPV1 AEA 2-AG OEA, LEA, DHEA 2-OG, 2-LG NATaus
TRPV2 OEA, LEA, as antagonists
TRPV3
TRPV4 NATaus
TRPA1
TRPM8 AEA, as antagonist 2-AG, as antagonist
  1. Note (alphabetical order): *Protein names are ordered in the rank of importance. 2-AG, 2-arachidonoylglycerol; 2-LG, 2-linoleoylglycerol; 2-MAGs, 2-monoacylglycerols; 2-OG, 2-oleoylglycerol; 2-PG, 2-palmitoylglycerol; ABHD4, 6, 12, ⍺/β-hydrolases 4, 6, 12; AEA, arachidonoylethanolamide; CB1, 2, cannabinoid receptors1, 2; COX-2, cyclooxygenase-2; DAGL-⍺/β, diacylglycerol lipase-⍺/β; DHEA, docosahexaenoylethanolamide; EPEA, eicosapentaenoylethanolamide; FAAH, fatty acid amide hydrolase; GDE1, glycerophosphodiester phosphodiesterase 1; GPR6, 18, 55, 110, 119, G protein-coupled receptors6, 18, 55, 110, 119; LEA, linoleoylethanolamide; MAGL, monoacylglycerol lipase; NAAs, N-acyl-amino acids; NAEs, N-acyl-ethanolamines; NAPE-PLD, N-acyl phosphatidylethanolamine phospholipase D; NAraG, N-arachidonoyl-glycine; NATaus, N-acyl taurines; NOleA, N-oleoyl-alanine; NOleG, N-oleyl-glycine; OEA, oleoylethanolamide; PEA, palmitoylethanolamide; PPAR-⍺/γ, peroxisome proliferator-activated receptors-alpha/gamma; TRPA1, transient receptor potential ankyrin 1; TRPM8, transient receptor potential melastatin 8; TRPV1, 2, 3, 4; transient receptor potential vanilloid 1, 2, 3, 4.