Triglyceride/low-density-lipoprotein cholesterol ratio is the most valuable predictor for increased small, dense LDL in type 2 diabetes patients

Ouchi, Gen; Komiya, Ichiro; Taira, Shinichiro; Wakugami, Tamio; Ohya, Yusuke

doi:10.1186/s12944-021-01612-8

Lipids in Health and Disease

Table 2 Simple regression analysis between LDL-MI and lipid markers in 110 type 2 diabetes patients with hypertriglyceridemia

From: Triglyceride/low-density-lipoprotein cholesterol ratio is the most valuable predictor for increased small, dense LDL in type 2 diabetes patients

Variables	r	SE	95% CI		P*	Adjusted R²
Variables	r	SE	Lower	Upper	P*	Adjusted R²
Total
TG, mmol/L	0.0188	0.0021	0.0147	0.0229	< 0.0001	0.4429
LDL-C, mmol/L	− 0.0183	0.0060	−0.0301	−0.0065	0.0027	0.0804
Non − HDL-C, mmol/L	0.0207	0.0050	0.0108	0.0307	< 0.0001	0.1359
TG/LDL-C ratio	0.0222	0.0030	0.0161	0.0282	< 0.0001	0.3299
TG/HDL-C ratio	0.0109	0.0015	0.0080	0.0139	< 0.0001	0.3390
LDL-C/HDL-C ratio	0.0019	0.0063	−0.0105	0.0144	0.7572	0.0009
Non − HDL-C/HDL-C ratio	0.0150	0.0027	0.0097	0.0203	< 0.0001	0.2252
LDL (PAG), %	−0.0021	0.0004	−0.0029	−0.0014	< 0.0001	0.2396
Midband (PAG), %	0.0031	0.0006	0.0020	0.0042	< 0.0001	0.2308
VLDL (PAG), %	0.0024	0.0006	0.0012	0.0036	0.0001	0.1309
With statins
TG, mmol/L	0.0156	0.0033	0.0089	0.0222	< 0.0001	0.3314
LDL-C, mmol/L	−0.0077	0.0094	−0.0266	0.0113	0.4203	0.0149
Non − HDL-C, mmol/L	0.0227	0.0072	0.0083	0.0372	0.0027	0.1826
TG/LDL-C ratio	0.0167	0.0045	0.0077	0.0258	0.0006	0.2349
TG/HDL-C ratio	0.0113	0.0027	0.0059	0.0167	0.0001	0.2825
LDL-C/HDL-C ratio	0.0049	0.0085	−0.0122	0.0220	0.5687	0.0073
Non − HDL-C/HDL-C ratio	0.0152	0.0045	0.0061	0.0243	0.0015	0.2018
LDL (PAG), %	−0.0016	0.0006	−0.0028	−0.0004	0.0110	0.1351
Midband (PAG), %	0.0033	0.0007	0.0020	0.0046	< 0.0001	0.3588
VLDL (PAG), %	0.0007	0.0010	−0.0013	0.0026	0.4999	0.0102
Without statins
TG, mmol/L	0.0199	0.0028	0.0145	0.0254	< 0.0001	0.4520
LDL-C, mmol/L	−0.0222	0.0076	−0.0374	−0.0070	0.0050	0.1222
Non − HDL-C, mmol/L	0.0181	0.0071	0.0038	0.0323	0.0139	0.0953
TG/LDL-C ratio	0.0240	0.0042	0.0157	0.0323	< 0.0001	0.3542
TG/HDL-C ratio	0.0106	0.0019	0.0068	0.0145	< 0.0001	0.3328
LDL-C/HDL-C ratio	0.0022	0.0088	−0.0198	0.0153	0.7994	0.0011
Non − HDL-C/HDL-C ratio	0.0143	0.0036	0.0071	0.0216	0.0002	0.2033
LDL (PAG), %	−0.0022	0.0005	−0.0032	−0.0013	< 0.0001	0.2668
Midband (PAG), %	0.0031	0.0008	0.0015	0.0047	0.0003	0.1975
VLDL (PAG), %	0.0028	0.0008	0.0012	0.0044	0.0007	0.1713

r: regression coefficient. SE: standard error. 95% CI: 95% confidence interval
TG triglycerides, LDL-C low-density lipoprotein cholesterol, Non − HDL-C non − high-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, HDL high-density lipoprotein, LDL low-density lipoprotein, VLDL very low-density lipoprotein, PAG polyacrylamide gel
^*Statistical analysis by least squares method

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