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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: Adipocyte-specific deletion of PIP5K1c reduces diet-induced obesity and insulin resistance by increasing energy expenditure

Fig. 3

Adipocyte-deficient of PIP5K1c show the improved metabolic profile under HFD feeding condition. a Blood glucose concentration during glucose tolerance tests (GTT) in HFD feeding WT and KO mice. b Area under curve (AUC) calculated based on panel a, N = 8–9/group. c Blood glucose concentration during insulin tolerance tests (ITT) in HFD feeding WT and KO mice. d Area under curve (AUC) calculated based on panel c, N = 8–9/group. e Organ mass of WT and KO mice after 16 weeks HFD feeding, N = 8–9/group. f Plasma triglyceride (TG), g total cholesterol (TCH), and h nonesterified fatty acid (NEFA) levels of WT and KO mice on HFD for 16 weeks, N = 7/group. i Representative image of H&E staining of liver from WT and KO mice with 16 weeks HFD diet. j, k Liver triglyceride (TG) and total cholesterol (TCH) content in WT and KO mice after 16 weeks HFD feeding, N = 6/group. l qPCR analysis of mRNA levels of lipogenesis genes in liver from WT and KO mice after 16 weeks HFD feeding. m qPCR analysis of mRNA levels of inflammation genes in livers from WT and KO mice after 16 weeks HFD feeding, N = 6 per group. *P < 0.05; **P < 0.01

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Lipids in Health and Disease

ISSN: 1476-511X