Fig. 4

PIP5K1c deficiency enhance energy expenditure in mice fed with HFD. a, b Carbon dioxide expiration (VCO2) and c, d oxygen consumption (VO2) was determined by metabolic cages in WT and KO mice after HFD feeding, N = 6/group. e, f Respiratory exchange ratio (RER) over 24 h for WT and KO mice after 16 weeks HFD feeding. g Energy expenditure (EE) was estimated by the amount of O2 consumption and CO2 production in WT and KO mice after 16 weeks HFD feeding, N = 6/group. *P < 0.05; **P < 0.01