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Table 2 Multivariate logistic regression of LAP and CMI for NAFLD

From: Sex-specific contribution of lipid accumulation product and cardiometabolic index in the identification of nonalcoholic fatty liver disease among Chinese adults

Variables

Odds Ratio (95%CI)

Crude

P value

Model 1

P value

Model 2

P value

Females

 LAP level (per 1 SD change)

1.068 (1.065,1.072)

<0.001

1.035 (1.031,1.039)

<0.001

1.026 (1.022,1.030)

0.002

 Quartiles of LAP

  Q1 (≤7.52)

1.000 (reference)

 

1.000 (reference)

 

1.000 (reference)

 

  Q2 (7.52–15.12)

7.639 (5.113,11.412)

<0.001

4.275 (2.831,6.456)

<0.001

3.437 (2.261,5.225)

<0.001

  Q3 (15.12–29.60)

28.840 (19.609,42.417)

<0.001

9.736 (6.481,14.623)

<0.001

6.575 (4.327,9.991)

<0.001

  Q4 (>29.60)

123.295 (83.913,181.159)

<0.001

24.822 (16.335,37.720)

<0.001

13.183 (8.512,20.417)

<0.001

  P value for trend

<0.001

<0.001

<0.001

 CMI level (per 1 SD change)

23.521 (19.410,28.503)

<0.001

8.114 (6.642,9.913)

<0.001

3.110 (2.579,3.750)

<0.001

 Quartiles of CMI

  Q1 (≤0.18)

1.000 (reference)

 

1.000 (reference)

 

1.000 (reference)

 

  Q2 (0.18–0.30)

4.211 (3.151,5.628)

<0.001

2.841 (2.100,3.843)

<0.001

2.246 (1.637,3.082)

<0.001

  Q3 (0.30–0.53)

10.103 (17.371,13.247)

<0.001

6.338 (4.758,8.443)

<0.001

3.983 (2.946,5.387)

<0.001

  Q4 (>0.53)

38.459 (50.347,65.909)

<0.001

18.746 (14.059,24.996)

<0.001

8.662 (6.371,11.778)

<0.001

  P value for trend

<0.001

<0.001

<0.001

Males

 LAP level (per 1 SD change)

1.063 (1.059,1.067)

<0.001

1.042 (1.038,1.046)

<0.001

1.033 (1.029,1.037)

<0.001

 Quartiles of LAP

  Q1 (≤16.02)

1.000 (reference)

 

1.000 (reference)

 

1.000 (reference)

 

  Q2 (16.02–28.52)

3.632 (3.142,4.199)

<0.001

2.288 (1.925,2.721)

<0.001

1.790 (1.491,2.148)

<0.001

  Q3 (28.52–50.00)

9.953 (8.501,11.653)

<0.001

5.087 (4.191,6.175)

<0.001

3.462 (2.810,4.265)

<0.001

  Q4 (>50.00)

32.922 (26.775,40.481)

<0.001

13.048 (10.205,16.683)

<0.001

7.544 (5.748,9.902)

<0.001

  P value for trend

<0.001

<0.001

<0.001

 CMI level (per 1 SD change)

9.435 (8.069,11.033)

<0.001

6.078 (5.162,7.156)

<0.001

3.069 (2.603,3.618)

<0.001

 Quartiles of CMI

  Q1 (≤0.36)

1.000 (reference)

 

1.000 (reference)

 

1.000 (reference)

 

  Q2 (0.36–0.62)

2.810 (2.442,3.233)

<0.001

2.467 (2.100,2.899)

<0.001

1.779 (1.492,2.122)

<0.001

  Q3 (0.62–1.05)

7.068 (6.068,8.234)

<0.001

5.247 (4.408,6.245)

<0.001

2.884 (2.379,3.496)

<0.001

  Q4 (>1.05)

17.978 (14.967,21.595)

<0.001

12.278 (9.990,15.089)

<0.001

5.400 (4.297,6.786)

<0.001

  P value for trend

<0.001

<0.001

<0.001

  1. Abbreviations: NAFLD nonalcoholic fatty liver disease, LAP lipid accumulation product, CMI cardiometabolic index. Crude: no adjustment; Model 1: adjusted for age, current smoking, regularly exercising, BMI. Model 2: adjusted for all the factors in Model 1 and WBC, SBP, TC, LDL-C, FPG, ALT, GGT, UA among males, additionally plus BUN among females
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Lipids in Health and Disease

ISSN: 1476-511X