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Table 1 Characteristics of the non-DR group and DR group

From: High remnant cholesterol level is relevant to diabetic retinopathy in type 2 diabetes mellitus

Variables

All (n = 456)

Non-DR (n = 239)

DR (n = 217)

P-value

Age (years)

53.54 ± 12.13 / 55 (44–63)

53 (40–62)

57 (47–64)

0.009**

Male gender, n (%)

292 (64)

161 (65.2)

131 (62.7)

0.579

Diabetes duration (years)

9.73 ± 6.97 / 9 (4–15)

7 (3–12)

11 (6–16)

0.001**

Hypertension, n (%)

232 (46.4)

105 (42.5)

127 (50.2)

0.085

Current smoking, n (%)

150 (32.9)

89 (36)

61 (29.2)

0.121

DNP, n (%)

175 (38.5)

79 (33.2)

96 (44.2)

0.027

BMI (kg/m2)

25.6 (23.92–27.95)

25.39 (23.84–27.39)

25.6 (23.98–28.09)

0.929

SBP (mmHg)

140 (126–150)

137 (123–150)

140 (130–154)

0.007*

DBP (mmHg)

80 (74–90)

80 (72–88)

81 (75–90)

0.067

FBG (mmol/L)

8.44 (6.88–10.61)

8.2 (6.79–10.54)

8.59 (7.04–10.71)

0.163

HbA1c (%)

8.4 (7.2–9.6)

8.2 (7.1–9.5)

8.5 (7.6–9.8)

0.076

HbA1c (mmol/mol)

68 (55–81)

66 (54–80)

69 (60–84)

0.057

Fasting C-Peptide (ng/ml)

1.5 (1.0–2.2)

1.55 (1.0–2.3)

1.5 (1.0–2.15)

0.426

Neutrophil (× 109/L)

3.71 (3.05–4.45)

3.48 (2.96–4.41)

3.85 (3.17–4.5)

0.01*

Lymphocyte (×109/L)

2.22 (1.78–2.64)

2.26 (1.87–2.69)

2.17 (1.73–2.56)

0.053

Monocyte (×109/L)

0.38 (0.31–0.45)

0.38 (0.3–0.45)

0.38 (0.31–0.44)

0.31

TC (mmol/L)

5.02 (4.42–5.74)

4.96 (4.24–5.58)

5.13 (4.58–5.96)

0.000**

TG (mmol/L)

2.18 (1.4–3.43)

2.12 (1.43–3.2)

2.31 (1.35–3.59)

0.286

HDL-C (mmol/L)

1.15 (0.99–1.3)

1.11 (0.99–1.28)

1.16 (1.00–1.325)

0.496

LDL-C (mmol/L)

3.09 (2.66–3.58)

3.14 (2.65–3.59)

3.05 (2.66–3.55)

0.822

APOA (g/L)

1.26 (1.13–1.39)

1.25 (1.14–1.39)

1.21 (1.11–1.40)

0.981

APOB (g/L)

1.03 (0.87–1.21)

1.035 (0.84–1.2)

1.03 (0.9–1.22)

0.2

RC (mmol/L)

0.65 (0.45–0.99)

0.54 (0.31–0.83)

0.74 (0.60–1.12)

0.000**

TyG-index

9.62 ± 0.78

9.52 ± 0.73

9.72 ± 0.82

0.006*

NLR

1.64 (1.36–2.03)

1.60 (1.30–1.93)

1.69 (1.41–2.26)

0.000**

Uric Acid (μmol/L)

329.3 (280.4–393.8)

326.3 (276.6–395)

330.8 (286.05–393.7)

0.644

Creatinine (μmol/L)

61.3 (50.6–70.5)

60.5 (50.45–70.13)

62.3 (51.1–72.4)

0.384

eGFR (ml/min/1.73m2)

108.6 (97.68–121.03)

110.96 (98.24–123.10)

106.27 (96–117.95)

0.013

mAlb (mg/24 h)

20.31 (19.76–33.63)

19.95 (19.57–23.56)

20.71 (19.95–56.53)

0.000**

Metformin, n (%)

277 (60.7)

149 (60.3)

128 (61.2)

0.841

DPP-IV inhibitor, n (%)

189 (41.4)

98 (39.7)

91 (43.5)

0.404

Acarbose, n (%)

68 (15.3)

38 (15.9)

30 (14.6)

0.712

Insulin, n (%)

139 (30.5)

72 (29.1)

67 (32.1)

0.502

Anitihypertensive drugs, n (%)

159 (34.9)

76 (30.8)

83 (39.7)

0.046*

  1. Abbreviations: DR diabetic retinopathy, DPN diabetic peripheral neuropathy, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, FBG Fasting blood glucose, APOA apolipoprotein A, APOB apolipoprotein B, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, RC remnant cholesterol, eGFR estimated glomerular filtration rate, HbA1c glycosylated hemoglobin, TyG-index triglyceride glucose index, NLR neutrophil to lymphocyte ratio, DR diabetic retinopathy, DPP-IV dipeptidyl peptidase-IV, mAlb microalbuminuria
  2. Notes: Data are expressed as mean ± SD, percentages, or as medians (IQR); p-values were compared by independent t-test, Mann-Whitney U test, or Chi-square test as appropriate.*P < 0.05, **P < 0. 001