Table 3 Association of energy-adjusted intake of dietary fat and fatty acids with the risk of ESCC
Dietary items§ | N (controls/cases) | Crude OR (95% CI) * | Adjusted OR (95% CI) *†| Adjusted OR (95% CI) *‡ |
|---|---|---|---|---|
Dietary fat | ||||
 Quintile 1 (≤48.25) | 179/192 | 1.00 | 1.00 | 1.00 |
 Quintile 2 (> 48.25 ~ ≤ 57.18) | 178/148 | 0.78 (0.57, 1.04) | 0.72 (0.52, 1.00) | 0.79 (0.55, 1.11) |
 Quintile 3 (> 57.18 ~ ≤ 65.89) | 178/176 | 0.92 (0.69, 1.23) | 0.98 (0.72, 1.35) | 1.07 (0.76, 1.50) |
 Quintile 4 (> 65.89 ~ ≤ 75.94) | 178/142 | 0.74 (0.55, 1.00) | 0.74 (0.54, 1.03) | 0.78 (0.54, 1.11) |
 Quintile 5 (> 75.94) | 179/221 | 1.15 (0.87, 1.53) | 1.10 (0.81, 1.49) | 1.22 (0.83, 1.80) |
 P for trend |  | 0.391 | 0.486 | 0.426 |
 Every 10-unit increment |  | 1.06 (1.01, 1.11) | 1.05 (1.00, 1.11) | 1.11 (1.04, 1.19) |
Total fatty acid | ||||
 Quintile 1 (≤46.05) | 179/227 | 1.00 | 1.00 | 1.00 |
 Quintile 2 (> 46.05 ~ ≤ 55.14) | 178/184 | 0.82 (0.61, 1.08) | 0.77 (0.56, 1.04) | 0.78 (0.56, 1.08) |
 Quintile 3 (> 55.14 ~ ≤ 63.65) | 178/176 | 0.78 (0.59, 1.04) | 0.80 (0.59, 1.10) | 0.77 (0.55, 1.08) |
 Quintile 4 (> 63.65 ~ ≤ 73.51) | 178/128 | 0.57 (0.42, 0.76) | 0.58 (0.42, 0.80) | 0.51 (0.35, 0.73) |
 Quintile 5 (> 73.51) | 179/164 | 0.72 (0.54, 0.96) | 0.67 (0.49, 0.91) | 0.57 (0.38, 0.85) |
 P for trend |  | 0.002 | 0.003 | 0.001 |
 Every 10-unit increment |  | 0.96 (0.92, 1.01) | 0.95 (0.91, 1.00) | 0.93 (0.87, 1.00) |
Saturated fatty acid | ||||
 Quintile 1 (≤13.25) | 179/190 | 1.00 | 1.00 | 1.00 |
 Quintile 2 (> 13.25 ~ ≤ 16.58) | 178/173 | 0.92 (0.68, 1.23) | 0.88 (0.64, 1.21) | 0.92 (0.65, 1.29) |
 Quintile 3 (> 16.58 ~ ≤ 19.04) | 178/167 | 0.88 (0.66, 1.19) | 0.88 (0.64, 1.22) | 0.92 (0.65, 1.30) |
 Quintile 4 (> 19.04 ~ ≤ 21.95) | 178/140 | 0.74 (0.55, 1.00) | 0.77 (0.56, 1.07) | 0.81 (0.56, 1.16) |
 Quintile 5 (> 21.95) | 179/209 | 1.10 (0.83, 1.46) | 1.02 (0.75, 1.39) | 0.96 (0.65, 1.42) |
 P for trend |  | 0.934 | 0.905 | 0.601 |
 Every 10-unit increment |  | 1.17 (1.00, 1.36) | 1.14 (0.97, 1.34) | 1.21 (0.96, 1.51) |
Monounsaturated fatty acid | ||||
 Quintile 1 (≤22.03) | 179/236 | 1.00 | 1.00 | 1.00 |
 Quintile 2 (> 22.03 ~ ≤ 26.8) | 178/226 | 0.96 (0.73, 1.27) | 0.98 (0.72, 1.32) | 0.93 (0.67, 1.29) |
 Quintile 3 (> 26.8 ~ ≤ 30.69) | 178/154 | 0.66 (0.49, 0.88) | 0.65 (0.47, 0.89) | 0.58 (0.41, 0.81) |
 Quintile 4 (> 30.69 ~ ≤ 35.23) | 178/121 | 0.52 (0.38, 0.70) | 0.54 (0.39, 0.75) | 0.45 (0.31, 0.64) |
 Quintile 5 (> 35.23) | 179/142 | 0.60 (0.45, 0.81) | 0.56 (0.41, 0.77) | 0.41 (0.27, 0.62) |
 P for trend |  | < 0.001 | < 0.001 | < 0.001 |
 Every 10-unit increment |  | 0.83 (0.74, 0.92) | 0.81 (0.72, 0.91) | 0.70 (0.59, 0.81) |
Polyunsaturated fatty acid | ||||
 Quintile 1 (≤10.11) | 179/260 | 1.00 | 1.00 | 1.00 |
 Quintile 2 (> 10.11 ~ ≤ 11.77) | 178/163 | 0.63 (0.47, 0.84) | 0.66 (0.48, 0.91) | 0.68 (0.48, 0.94) |
 Quintile 3 (> 11.77 ~ ≤ 13.76) | 178/151 | 0.58 (0.44, 0.78) | 0.62 (0.45, 0.85) | 0.62 (0.44, 0.89) |
 Quintile 4 (> 13.76 ~ ≤ 16.42) | 178/164 | 0.63 (0.48, 0.84) | 0.69 (0.5, 0.94) | 0.64 (0.45, 0.91) |
 Quintile 5 (> 16.42) | 179/141 | 0.54 (0.40, 0.73) | 0.57 (0.41, 0.78) | 0.56 (0.37, 0.83) |
 P for trend |  | < 0.001 | 0.001 | 0.007 |
 Every 10-unit increment |  | 0.80 (0.67, 0.95) | 0.80 (0.66, 0.96) | 0.85 (0.66, 1.10) |