Table 4 Stratified analysis by cigarette smoking on the association of dietary fat and fatty acids intake with the risk of ESCC
| Â | Non-smoker | Smoker | ||||
|---|---|---|---|---|---|---|
N (controls/cases) | Crude OR (95% CI) * | Adjusted OR (95% CI) *†| N (controls/cases) | Crude OR (95% CI) * | Adjusted OR (95% CI) *†| |
Dietary fat | ||||||
 Quintile 1 (≤43.81 μg/day) | 123/80 | 1.00 | 1.00 | 57/95 | 1.00 | 1.00 |
 Quintile 2 (> 43.81 ~ ≤ 55.64 μg/day) | 94/71 | 1.16 (0.76, 1.76) | 1.04 (0.64, 1.67) | 79/110 | 0.84 (0.54, 1.29) | 0.72 (0.43, 1.20) |
 Quintile 3 (> 55.64 ~ ≤ 65.04 μg/day) | 108/58 | 0.83 (0.54, 1.26) | 0.78 (0.47, 1.29) | 88/100 | 0.68 (0.44, 1.05) | 0.59 (0.35, 1.00) |
 Quintile 4 (> 65.04 ~ ≤ 79.11 μg/day) | 118/65 | 0.85 (0.56, 1.28) | 0.75 (0.44, 1.28) | 70/101 | 0.87 (0.55, 1.35) | 0.72 (0.41, 1.27) |
 Quintile 5 (> 79.11 μg/day) | 91/69 | 1.17 (0.76, 1.78) | 1.02 (0.52, 1.99) | 64/130 | 1.22 (0.78, 1.90) | 1.41 (0.71, 2.82) |
 P for trend |  | 0.946 | 0.472 |  | 0.294 | 0.638 |
 Every 10-unit increment |  | 1.05 (1.00, 1.11) | 1.10 (1.00, 1.21) |  | 1.06 (1.00, 1.12) | 1.11 (1.00, 1.23) |
Total fatty acid | ||||||
 Quintile 1 (≤40.93 μg/day) | 108/87 | 1.00 | 1.00 | 53/108 | 1.00 | 1.00 |
 Quintile 2 (> 40.93 ~ ≤ 52.01 μg/day) | 91/76 | 1.04 (0.68, 1.57) | 0.86 (0.53, 1.38) | 66/119 | 0.88 (0.57, 1.38) | 0.68 (0.40, 1.13) |
 Quintile 3 (> 52.01 ~ ≤ 60.91 μg/day) | 107/61 | 0.71 (0.46, 1.08) | 0.53 (0.32, 0.87) | 88/98 | 0.55 (0.35, 0.84) | 0.40 (0.24, 0.68) |
 Quintile 4 (> 60.91 ~ ≤ 74.48 μg/day) | 121/59 | 0.61 (0.40, 0.92) | 0.41 (0.23, 0.70) | 75/99 | 0.65 (0.41, 1.01) | 0.39 (0.22, 0.68) |
 Quintile 5 (> 74.48 μg/day) | 107/60 | 0.70 (0.45, 1.06) | 0.35 (0.18, 0.69) | 76/112 | 0.72 (0.46, 1.12) | 0.46 (0.23, 0.90) |
 P for trend |  | 0.009 | < 0.001 |  | 0.066 | 0.002 |
 Every 10-unit increment |  | 0.99 (0.93, 1.05) | 0.92 (0.83, 1.02) |  | 0.99 (0.93, 1.05) | 0.92 (0.83, 1.02) |
Saturated fatty acid | ||||||
 Quintile 1 (≤11.99 μg/day) | 117/75 | 1.00 | 1.00 | 60/103 | 1.00 | 1.00 |
 Quintile 2 (> 11.99 ~ ≤ 15.94 μg/day) | 95/79 | 1.30 (0.86, 1.97) | 1.13 (0.70, 1.82) | 80/100 | 0.73 (0.47, 1.12) | 0.61 (0.37, 1.01) |
 Quintile 3 (> 15.94 ~ ≤ 18.6 μg/day) | 116/64 | 0.86 (0.56, 1.31) | 0.79 (0.48, 1.29) | 71/103 | 0.85 (0.54, 1.31) | 0.66 (0.39, 1.11) |
 Quintile 4 (> 18.6 ~ ≤ 22.92 μg/day) | 111/62 | 0.87 (0.57, 1.33) | 0.66 (0.39, 1.11) | 78/103 | 0.77 (0.50, 1.19) | 0.55 (0.32, 0.94) |
 Quintile 5 (> 22.92 μg/day) | 95/63 | 1.03 (0.67, 1.59) | 0.70 (0.35, 1.38) | 69/127 | 1.07 (0.69, 1.65) | 1.02 (0.53, 1.97) |
 P for trend |  | 0.491 | 0.068 |  | 0.602 | 0.673 |
 Every 10-unit increment |  | 1.15 (0.95, 1.38) | 1.13 (0.81, 1.57) |  | 1.18 (0.98, 1.42) | 1.23 (0.89, 1.70) |
Monounsaturated fatty acids | ||||||
 Quintile 1 (≤19.48 μg/day) | 107/89 | 1.00 | 1.00 | 51/109 | 1.00 | 1.00 |
 Quintile 2 (> 19.48 ~ ≤ 25 μg/day) | 83/84 | 1.22 (0.80, 1.84) | 1.04 (0.65, 1.68) | 61/125 | 0.96 (0.61, 1.51) | 0.73 (0.44, 1.23) |
 Quintile 3 (> 25 ~ ≤ 29.25 μg/day) | 107/58 | 0.65 (0.42, 1.00) | 0.45 (0.27, 0.75) | 85/103 | 0.57 (0.36, 0.88) | 0.38 (0.22, 0.64) |
 Quintile 4 (> 29.25 ~ ≤ 35.25 μg/day) | 123/57 | 0.56 (0.36, 0.85) | 0.32 (0.19, 0.55) | 85/90 | 0.50 (0.32, 0.77) | 0.29 (0.16, 0.50) |
 Quintile 5 (> 35.25 μg/day) | 114/55 | 0.58 (0.38, 0.89) | 0.23 (0.12, 0.46) | 76/109 | 0.67 (0.43, 1.04) | 0.36 (0.18, 0.70) |
 P for trend |  | < 0.001 | < 0.001 |  | 0.004 | < 0.001 |
 Every 10-unit increment |  | 0.89 (0.78, 1.02) | 0.67 (0.53, 0.84) |  | 0.9 (0.79, 1.03) | 0.68 (0.54, 0.85) |
Polyunsaturated fatty acid | ||||||
 Quintile 1 (≤8.88 μg/day) | 98/91 | 1.00 | 1.00 | 50/116 | 1.00 | 1.00 |
 Quintile 2 (> 8.88 ~ ≤ 10.85 μg/day) | 104/67 | 0.69 (0.46, 1.05) | 0.57 (0.35, 0.93) | 62/121 | 0.84 (0.53, 1.32) | 0.68 (0.41, 1.14) |
 Quintile 3 (> 10.85 ~ ≤ 13.22 μg/day) | 106/54 | 0.55 (0.35, 0.84) | 0.48 (0.28, 0.80) | 99/94 | 0.41 (0.26, 0.63) | 0.25 (0.14, 0.43) |
 Quintile 4 (> 13.22 ~ ≤ 16.55 μg/day) | 111/74 | 0.72 (0.48, 1.08) | 0.53 (0.31, 0.91) | 67/102 | 0.66 (0.42, 1.03) | 0.41 (0.23, 0.74) |
 Quintile 5 (> 16.55 μg/day) | 115/57 | 0.53 (0.35, 0.82) | 0.31 (0.16, 0.60) | 80/103 | 0.55 (0.36, 0.86) | 0.27 (0.13, 0.53) |
 P for trend |  | 0.010 | 0.002 |  | 0.006 | < 0.001 |
 Every 10-unit increment |  | 0.95 (0.76, 1.17) | 0.92 (0.64, 1.30) |  | 0.87 (0.70, 1.09) | 0.72 (0.49, 1.05) |