Table 1 Characteristics of the patients at baseline or during follow-up
All patients (n=5340) | Therapy Statusa | LDL variabilityb | ||||
|---|---|---|---|---|---|---|
Fenofibrate (n=2673) | Placebo (n=2667) | VIM <13.2 (n=2665) | VIM ≥13.2 (n=2675) | P | ||
At baseline | ||||||
Age | 62.8±6.6 | 62.8±6.5 | 62.8±6.7 | 62.9±6.6 | 62.6±6.5 | 0.06 |
Female sex (n, %) | 1632 (30.6) | 817 (30.6) | 815 (30.6) | 770 (28.9) | 862 (32.2) | 0.008 |
Weight | 94.9±18.3 | 94.6±18.2 | 95.2±18.5 | 95.6±17.9 | 94.3±18.7 | 0.009 |
Body-mass index | 32.3±5.3 | 32.2±5.3 | 32.4±5.3 | 32.4±5.3 | 32.2±5.4 | 0.28 |
Waist circumference (cm) | 107.7±13.5 | 107.5±13.3 | 107.8±13.7 | 108.1±13.4 | 107.2±13.6 | 0.02 |
Systolic blood pressure (mmHg) | 133.9±17.7 | 133.8±17.6 | 133.9±17.9 | 132.2±17.2 | 135.5±18.1 | <0.0001 |
Diastolic blood pressure (mmHg) | 74.0±10.8 | 73.8±10.6 | 74.1±10.9 | 73.1±10.6 | 74.8±10.9 | <0.0001 |
Fasting serum glucose (mg/dL) | 175.8±54.6 | 176.3±54.1 | 175.3±55.1 | 170.7±51.8 | 180.8±56.8 | <0.0001 |
Total cholesterol (mg/dL) | 175.3±37.4 | 174.9±36.8 | 175.7±38.0 | 162.8±28.2 | 187.8±41.1 | <0.0001 |
LDL cholesterol (mg/dL) | 100.6±30.7 | 100.0±30.2 | 101.2±31.0 | 91.5±24 | 109.6±33.8 | <0.0001 |
HDL cholesterol (mg/dL) | 38.1±7.8 | 38.0±7.8 | 38.2±7.7 | 38.5±7.7 | 37.7±7.8 | 0.0005 |
Plasma triglyceride (mg/dL) | 188.0±113 | 189.7±111,5 | 186.3±114.6 | 167±91.1 | 208.9±127.9 | <0.0001 |
Serum creatinine (mg/dL) | 0.92±0.22 | 0.93±0.23 | 0.93±0.22 | 0.92±0.23 | 0.93±0.21 | 0.04 |
Lipids during follow-up | ||||||
Mean total cholesterol (mg/dL) | 160.6±26.8 | 158.3±26.2 | 162.9±27.2* | 156.9±23.6 | 164.3±29.1 | <0.0001 |
Mean plasma triglyceride (mg/dL) | 165.5±88.5 | 152.5±80.6 | 178.6±94.0* | 151.4±72.6 | 179.5±100 | <0.0001 |
Mean HDL cholesterol (mg/dL) | 39.9±8.2 | 40.2±8.7 | 39.5±7.8* | 40.5±8.3 | 39.2±8.1 | <0.0001 |
Mean LDL cholesterol (mg/dL) | 88.4±19.8 | 88.2±19.9 | 88.6±19.7 | 86.6±18.4 | 90.1±21.0 | <0.0001 |
Maximum LDL cholesterol (mg/dL) | 120.1±29.6 | 119.0±29.6 | 121.3±29.5* | 107.4±22.7 | 132.8±30.2 | <0.0001 |
Minimum LDL cholesterol (mg/dL) | 64.2±17.8 | 64.7±17.5 | 63.7±18.0‡ | 68.2±17.1 | 60.1±17.5 | <0.0001 |
LDL SD | 19.3±8.8 | 18.7±8.8 | 19.9±8.8* | 13.5±4.8 | 25.1±8.1 | <0.0001 |
LDL CV (%) | 22.1±9.2 | 21.4±9.0 | 22.7±9.4* | 15.8±5.3 | 28.3±8.0 | <0.0001 |
LDL VIM | 13.9±6.0 | 13.8±6.0 | 14.1±5.9 | 9.3±2.5 | 18.5±4.8 | <0.0001 |
LDL ARV | 18.4±9.6 | 17.7±9.5 | 19.0±9.6* | 13.7±5.8 | 23.0±10.3 | <0.0001 |