Outcomes | Model | Total population (n=5340) | Fenofibrate (n=2673) | Placebo (n=2667) | |||
---|---|---|---|---|---|---|---|
HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | ||
Primary outcome | |||||||
Mean (+20 mg/dL) | Model 1 | 1.32 (1.16-1.33) | 0.001 | 1.31 (1.19-1.45) | <0.0001 | 1.34 (1.16-1.54) | <0.0001 |
CV (+9.2%) | Model 1 | 1.19 (1.10-1.29) | <0.0001 | 1.31 (1.17-1.46) | <0.0001 | 1.09 (0.97-1.22) | 0.13 |
Model 2 | 1.22 (1.13-1.32) | <0.0001 | 1.32 (1.19-1.48) | <0.0001 | 1.12 (1.00-1.26) | 0.04 | |
VIM (+6 U) | Model 1 | 1.21 (1.12-1.31) | <0.0001 | 1.32 (1.18-1.48) | <0.0001 | 1.10 (0.98-1.23) | 0.08 |
Model 2 | 1.22 (1.13-1.33) | <0.0001 | 1.33 (1.19-1.49) | <0.0001 | 1.13 (1.00-1.26) | 0.04 | |
ARV (+10 mg/dL) | Model 1 | 1.28 (1.19-1.38) | <0.0001 | 1.32 (1.18-1.43) | <0.0001 | 1.24 (1.11-1.39) | <0.0001 |
Model 2 | 1.27 (1.17-1.38) | <0.0001 | 1.36 (1.19-1.49) | <0.0001 | 1.19 (1.05-1.35) | 0.005 | |
Total mortality | |||||||
Mean (+20 mg/dL) | Model 1 | 1.32 (1.19-1.46) | <0.0001 | 1.25 (1.07-1.46) | 0.004 | 1.37 (1.20-1.56) | <0.0001 |
CV (+9.2%) | Model 1 | 1.07 (0.97-1.18) | 0.19 | 1.26 (1.10-1.44) | 0.001 | 0.93 (0.81-1.07) | 0.29 |
Model 2 | 1.12 (1.01-1.23) | 0.03 | 1.29 (1.13-1.49) | 0.0003 | 0.98 (0.85-1.13) | 0.77 | |
VIM (+6 U) | Model 1 | 1.15 (1.05-1.27) | 0.004 | 1.26 (1.12-1.43) | 0.0003 | 1.06 (0.92-1.22) | 0.45 |
Model 2 | 1.13 (1.03-1.25) | 0.01 | 1.25 (1.10-1.42) | 0.0007 | 1.04 (0.90-1.19) | 0.63 | |
ARV (+10 mg/dL) | Model 1 | 1.37 (1.26-1.49) | <0.0001 | 1.35 (1.21-1.52) | <0.0001 | 1.40 (1.24-1.59) | <0.0001 |
Model 2 | 1.29 (1.17-1.42) | <0.0001 | 1.31 (1.15-1.51) | <0.0001 | 1.29 (1.12-1.48) | 0.0006 | |
Cardiovascular mortality | |||||||
Mean (+20 mg/dL) | Model 1 | 1.34 (1.16-1.54) | <0.0001 | 1.30 (1.05-1.62) | 0.018 | 1.36 (1.13-1.64) | 0.001 |
CV (+9.2%) | Model 1 | 1.04 (0.90-1.20) | 0.59 | 1.33 (1.10-1.61) | 0.003 | 0.83 (0.67-1.01) | 0.07 |
Model 2 | 1.09 (0.94-1.26) | 0.27 | 1.37 (1.13-1.66) | 0.001 | 0.86 (0.70-1.07) | 0.17 | |
VIM (+6 U) | Model 1 | 1.17 (1.02-1.34) | 0.02 | 1.38 (1.18-1.61) | <0.0001 | 0.96 (0.78-1.18) | 0.68 |
Model 2 | 1.15 (1.00-1.31) | 0.047 | 1.35 (1.16-1.59) | 0.0002 | 0.94 (0.76-1.15) | 0.53 | |
ARV (+10 mg/dL) | Model 1 | 1.37 (1.22-1.55) | <0.0001 | 1.44 (1.24-1.68) | <0.0001 | 1.29 (1.07-1.55) | 0.008 |
Model 2 | 1.28 (1.11-1.47) | 0.0006 | 1.40 (1.17-1.68) | 0.0003 | 1.15 (0.93-1.42) | 0.19 |