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Table 3 Hazard ratios for top decile of maximum and minimum LDL cholesterol during follow-up for Outcomes

From: Prognostic significance of visit-to-visit variability, and maximum and minimum LDL cholesterol in diabetes mellitus

 

Total population (n=5340)

Fenofibrate (n=2673)

Placebo (n=2667)

 

HR (95%CI)

P

HR (95%CI)

P

HR (95%CI)

P

Maximum LDL_C

      

+1 SD (30 mg/dL)

      

Primary outcome

1.10 (1.01-1.20)

0.04

1.15 (1.01-1.31)

0.03

1.15 (1.01-1.31)

0.03

All-cause deaths

1.12 (1.01-1.23)

0.04

1.16 (0.99-1.34)

0.06

1.08 (0.94-1.24)

0.30

Cardiovascular deaths

1.15 (0.99-1.33)

0.054

1.26 (1.02-1.56)

0.03

1.05 (0.87-1.28)

0.60

≥70 vs. <70 mg/dL

      

Primary outcome

0.85 (0.48-1.52)

0.59

0.75 (0.33-1.69)

0.49

0.98 (0.43-2.20)

0.95

All-cause deaths

0.61 (0.34-1.12)

0.11

0.50 (0.21-1.24)

0.13

0.70 (0.31-1.61)

0.40

Cardiovascular deaths

0.48 (0.23-1.03)

0.06

0.62 (0.15-2.56)

0.51

0.43 (0.17-1.07)

0.07

Minimum LDL_C

      

+1 SD (18 mg/dL)

      

Primary outcome

1.54 (1.41-1.67)

<0.0001

1.48 (1.31-1.68)

<0.0001

1.60 (1.42-1.80)

<0.0001

All-cause deaths

1.41 (1.28-1.56)

<0.0001

1.31 (1.13-1.53)

0.0005

1.50 (1.31-1.70)

<0.0001

Cardiovascular deaths

1.54 (1.34-1.77)

<0.0001

1.43 (1.15-1.78)

0.001

1.63 (1.36-1.96)

<0.0001

≥70 vs. <70 mg/dL

      

Primary outcome

2.11 (1.77-2.52)

<0.0001

1.95 (1.51-2.52)

<0.0001

2.30 (1.79-2.94)

<0.0001

All-cause deaths

1.60 (1.31-1.97)

<0.0001

1.48 (1.10-1.99)

0.01

1.73 (1.30-2.28)

0.0001

Cardiovascular deaths

2.03 (1.52-2.70)

<0.0001

1.70 (1.11-2.60)

0.02

2.39 (1.61-3.53)

<0.0001

  1. All models were adjusted for therapy group (if applicable), sex, and baseline age, education, body mass index, systolic and diastolic blood pressure, smoking, drinking, and fasting plasma glucose