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Table 3 Threshold effect analysis of MHR on mortality using the two-piecewise regression model

From: Monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) and the risk of all-cause and cardiovascular mortality: a nationwide cohort study in the United States

 

All-cause mortality

HR (95%CI) P-value

Cardiovascular mortality

HR (95%CI) P-value

Model I

 One line

1.12 (1.06, 1.17) < 0.001

1.21 (1.07, 1.36) 0.002

Model II

 Inflection value

0.006

0.005

  < threshold value

0.68 (0.58, 0.82) < 0.001

0.76 (0.43, 1.37) 0.364

  ≥ threshold value

1.20 (1.13, 1.27) < 0.001

1.25 (1.10, 1.42) < 0.001

 P for log-likelihood ratio test†

< 0.001

0.151

  1. CI Confidence interval, HR Hazard ratio, MHR Monocyte-to-high-density lipoprotein-cholesterol ratio
  2. MHR was log2-transformed to fit the Cox regression model. Analysis was adjusted for age, gender, ethnicity, smoker, drinker, DM, hypertension, HF, CHD, stroke, cancer, BMI, hemoglobin, platelets, LDL-C, triglyceride, albumin, and eGFR.analysis.
  3. †Model II vs. Model I