Skip to main content

Table 1 TEWL and Impedance evaluated as differences from Day 1 in Delta-5 oil-SLS damaged and untreated damaged groups at various time points

From: Delta-5® oil, containing the anti-inflammatory fatty acid sciadonic acid, improves skin barrier function in a skin irritation model in healthy female subjects

Time points/Means

D2-D1

D3-D1

D7-D1

D28-D1

 

TEWL With Control Normalization

Damaged Untreated

0.54 ± 3.23

-1.45 ± 3.37

-3.32 ± 3.51

-4.14 ± 3.47

Damaged Treated

-0.45 ± 4.09

-3.26 ± 3.98*

-5.76 ± 4.47**

-7.02 ± 4.68**

P-Value

0.24

0.03

0.01

0.01

% difference

 

125.2

73.6

69.4

 

TEWL Without Control Normalization

Damaged Untreated

0.84 ± 10.42

-5.14 ± 12.99

-12.46 ± 13.61

-15.86 ± 13.35

Damaged Treated

-4.53 ± 16.31

-12.36 ± 17.35

-22.80 ± 17.93*

-27.60 ± 18.52**

P-Value

0.17

0.06Trend

0.02

0.01

% difference

 

140.3

83.0

74.1

 

Impedance Without Control Normalization

Damaged Untreated

14.67 ± 84.85

-28.67 ± 119.75

-40.00 ± 118.30

-8.00 ± 98.20

Damaged Treated

-3.33 ± 100.20

-73.67 ± 148.65**

-82.00 ± 140.76*

-42.33 ± 145.19

P-Value

0.14

0.01

0.02

0.08Trend

% difference

 

157.0

105.0

429.2

  1. Values represent means for differences from each time point from day 1 ± 1 SD for 6–7 subjects. Units for TEWL are g/m2h; units for impedance are in arbitrary Dermal Phase Meter impedance units (DPMIU). For impedance, subject 589,750 was excluded due to missing values and an outlying value (n = 6). Values from each time point were either normalized by the corresponding untreated control value for the corresponding time points, or not, as indicated. Asterisks are indicated as*p ≤ 0.05; **p ≤ 0.01, with p-values from 1-tailed, paired tests also provided (see 17 section for details). Percents represent percent differences between treated- and untreated groups at each time point interval, and are provided when the p-value was between 0.05 and 0.10, as indicated as a statistical trend (“Trend”)