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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: Lipidomic analysis identifies age-disease-related changes and potential new biomarkers in brain-derived extracellular vesicles from metachromatic leukodystrophy mice

Fig. 5

Relative ceramide levels observed in the brain derived EVs from MLD and control mice. Relative levels of ceramides were plotted for A) ceramide alpha-hydroxy fatty acid-sphingosine (Cer_AS), B) ceramide non-hydroxyfatty acid sphingone (Cer_NS), C) d18:1 Cer_NS isomers, D) Long chain Cer_NS (> 20 carbons), E) ceramide non-hydroxyfatty acid-dihydrosphingosine (Cer_NDS) and F) long chain Cer_NS lipid species at 30 postnatal days (P30, green), 3 months (3 m, orange) and 6 months (6 m, blue) of age for control (ARSA+/+) and MLD mice (ARSA−/−). Error bars represent mean ± SEM, n = 3 biological replicates per genotype and time point. Significance was determined via an unpaired t-test (p < 0.05, * p < 0.01, **; p < 0.001, ***)

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