Fig. 6From: Lipidomic analysis identifies age-disease-related changes and potential new biomarkers in brain-derived extracellular vesicles from metachromatic leukodystrophy miceRelative galactosylceramide and sulfatide levels observed in the brain derived EVs from MLD and control mice. Relative levels of galactosylceramide (HexCer) and sulfatides (SHexCer were plotted for A) hexosylceramide non- hydroxyfatty acid-phingosine (HexCer_NS), B) Long chain HexCer_NS (> 20 carbons), C) hexosylceramide non-hydroxyfatty acid-dihydrosphingosine (HexCer_NDS), D) sulfatides (SHexCer) at 30 postnatal days (P30, green), 3 months (3 m, orange) and 6 months (6 m, blue) of age for control (ARSA+/+) and MLD (ARSA−/−) mice. Error bars represent mean ± SEM, n = 3 biological replicates per genotype and time point. Significance was determined via an unpaired t-test (p < 0.05, * p < 0.01, **; p < 0.001, ***)Back to article page