Table 1 Lipids identified from EVs by differential lipidomics in MLD versus control

1

HexCer_NS d18:1_16:0 (+)

2.6***

3.8***

7.9***

2

HexCer_NS d18:1_18:0 (+)

−1.2

− 1.1

1.2 *

3

HexCer_NS d18:1_18:1 (+)

1.5

2.0 **

3.6***

4

HexCer_NS d18:1_22:0 (+)

1.0

−1.3

1.1 *

5

HexCer_NS d18:1_22:1 RT:10.345 (+)

−1.1

− 1.3

1.1 *

6

HexCer_NS d18:1_22:1 RT:9.311 (+)

−1.0

− 1.2

1.1 *

7

HexCer_NS d18:1_24:1 (+)

−1.1

−1.4

− 1.1 *

8

HexCer_NS d18:2_18:0 (+)

1.8 *

1.7 *

2.9***

9

HexCer_NS d42:3 (−)

1.0

−1.5

−1.2 *

10

HexCer_NDS d40:1 (−)

1.1

−1.3

1.1 *

11

HexCer_NDS d40:2 (−)

1.0

−1.1

1.1 *

12

Cer_AS d36:1 (−)

1.2

−1.2

−1.1 **

13

Cer_AS d40:1 (−)

1.5

1.5

2.1***

14

Cer_AS d42:1 (−)

1.6 *

1.7

1.8***

15

Cer_NDS d16:0_26:2 (−)

−1.0

−1.6 *

−1.4 *

16

Cer_NDS d18:0_16:0 (−)

−1.1

−1.3

− 1.6 *

17

Cer_NDS d18:0_18:0 (−)

1.1

−1.5

−1.5 *

18

Cer_NDS d18:0_18:0 (+)

−1.1

−1.5

− 1.5 *

19

Cer_NDS d18:0_22:0 (−)

−1.1

− 1.3

−1.3 *

20

Cer_NDS d20:0_18:0 (−)

1.0

−1.3

−1.1 **

21

Cer_NDS d40:1 (−)

1.0

−1.5

−1.4 **

22

Cer_NDS d42:1 (−)

1.0

−1.5

−1.3 *

23

Cer_NS d18:1_14:0 (+)

−1.7

−1.1

− 1.2 *

24

Cer_NS d18:1_18:0 (+)

−1.1

−1.3

− 1.2 *

25

Cer_NS d18:1_22:0 (+)

−1.1

−1.5

− 1.5 **

26

Cer_NS d18:1_22:1 (+)

− 1.0

−1.6

− 1.5 *

27

Cer_NS d18:1_24:0 RT:12.277 (+)

− 1.2

−1.5 *

− 1.4 *

28

Cer_NS d18:1_24:0 RT:13.671 (+)

− 1.1

−1.6 *

− 1.3 *

29

Cer_NS d18:1_24:1 RT:10.678 (+)

− 1.0

−1.5 *

− 1.1 **

30

Cer_NS d18:1_24:1 RT:11.654 (+)

− 1.2

−1.8 **

− 1.7***

31

Cer_NS d18:1_24:1 RT:12.272 (+)

− 1.1

−1.6

− 1.4 *

32

Cer_NS d18:1_24:1 (−)

−1.0

− 1.6 *

−1.4 *

33

Cer_NS d18:1_24:2 (+)

−1.1

−1.8

− 1.4 *

34

Cer_NS d18:1_24:2 (−)

1.1

−1.6

−1.5 *

35

Cer_NS d18:2_18:0 (−)

1.0

−1.2 *

− 1.1

36

Cer_NS d18:2_18:0 (+)

1.1

−1.2 *

−1.1 **

37

Cer_NS d18:2_20:0 (−)

1.2

−1.5

−1.2 *

38

Cer_NS d18:2_20:0 (+)

−1.0

−1.4 *

− 1.2 *

39

Cer_NS d18:2_22:0 (−)

1.4

−1.6

−2.1 *

40

Cer_NS d18:2_22:0 (+)

1.2

−1.5

−2.0 *

41

Cer_NS d18:2_24:0 (+)

−1.1

−1.6

− 1.4 *

42

Cer_NS d20:1_18:0 (−)

1.1

−1.4

−1.3 **

43

Cer_NS d20:1_18:0 (+)

−1.1

−1.4

− 1.3***

44

Cer_NS d42:1 (−)

−1.1

− 1.6

−1.5 *

45

Cer_NS d42:2 (−)

−1.0

−1.6 *

− 1.4 *

46

Cer_NS d46:1 (−)

2.0 *

1.4

1.0

47

SHexCer d18:1_16:0 (+)

−1.2

−1.0

1.3 *

48

SHexCer d36:1 (−)

1.6

1.9 *

4.6***

49

SHexCer d40:1 (−)

1.3

1.1

2.0***