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Table 1 Changes of body weight, liver/body weight as well as blood levels of glucose, insulin, and ketone bodies in adult male wildtype, HNF4α heterozygote, and HNF4α knockout mice fed the high-fat-high-sugar diet for 15 d

From: Crosstalk of hepatocyte nuclear factor 4a and glucocorticoid receptor in the regulation of lipid metabolism in mice fed a high-fat-high-sugar diet

  Wildtype Heterozygote Knockout
Body weight (Day0) (g) 23.6 ± 0.6 25.0 ± 0.5 23.7 ± 0.5
Body weight (Day15) (g) 24.9 ± 0.9 25.7 ± 0.5 21.7 ± 1.0
Liver/body weight (g/100 g) 4.25 ± 0.11 5.00 ± 0.19 * 6.25 ± 0.21 *
Glucose (mg/dl) 199 ± 5 180 ± 7 130 ± 9 *
Insulin (nM) 0.21 ± 0.02 0.21 ± 0.06 0.13 ± 0.02 *
Ketone body (μM) 205 ± 8 333 ± 46 * 264 ± 11 *
  1. N=6-7 per group, mean ± SE. * P < 0.05 versus wildtype mice