Table 1 Changes of body weight, liver/body weight as well as blood levels of glucose, insulin, and ketone bodies in adult male wildtype, HNF4α heterozygote, and HNF4α knockout mice fed the high-fat-high-sugar diet for 15 d

Body weight (Day0) (g)

23.6 ± 0.6

25.0 ± 0.5

23.7 ± 0.5

Body weight (Day15) (g)

24.9 ± 0.9

25.7 ± 0.5

21.7 ± 1.0

Liver/body weight (g/100 g)

4.25 ± 0.11

5.00 ± 0.19 *

6.25 ± 0.21 *

Glucose (mg/dl)

199 ± 5

180 ± 7

130 ± 9 *

Insulin (nM)

0.21 ± 0.02

0.21 ± 0.06

0.13 ± 0.02 *

Ketone body (μM)

205 ± 8

333 ± 46 *

264 ± 11 *