Table 1 Characteristics of 18 observational studies
Author, year | Country | Sample Number | Proportion of males (%) | Age (years) | Follow-up (years) | Subjects | Endpoints | Donor Cell line | Labeling of cholesterol | Cholesterol acceptor |
|---|---|---|---|---|---|---|---|---|---|---|
Cohort studies | ||||||||||
 Rohatgi A [22], 2014 | USA | 132 cases | NA | 30–65 | Median 9.4 | Non-CAD | 1,2 | J 774 | BODIPY-C | ABDP |
 Liu C [36], 2016 | China | 122 cases | NA | 40–85 | 3.8 | CAD | 2 | J 774 | BODIPY-C | ABDS |
 Ritsch A [41], 2020 | Austria | 448 cases | NA | 62.8 ± 10.4 | Median 9.9 | Non-CAD | 2 | J 774 | 3 H-C | ABDS |
 Kuusisto S [34], 2019 | UK | 574 cases | NA | 25–74 | 15 | Non-CAD | 1 | J 774 | 3 H-C | ABDS |
Case-control studies | ||||||||||
 Saleheen D [42], 2015 | USA | Case: 1745 Control: 1749 | 68 | 40–79 | 14 | Case: CAD Control: non-CAD | 1 | J 774 | 3 H-C | ABDS |
 Zhang J [46], 2016 | China | Case: 214 Control:116 | 78 | 67 ± 11 | 1 | Case: CAD Control: non-CAD | 1,2 | J 774 | 3 H-C | ABDS |
 Li XM [35], 2013 | China | Cohort A: Case 871 Control: 279 Cohort B: Case: 146 Control: 431 | 67 70 | 64 ± 11 | 3 | Case: CAD Control: non-CAD | 1 | J 774 | 3 H-C | ABDS |
 Shea S [44], 2019 | USA | Case: 270 Control: 270 | NA | 45–85 | 10 | Case: CAD Control: non-CAD | 1 | THP-1 monocytes | 3 H-C | UCH |
 Patel P [40], 2013 | USA | Case: 23 Control: 46 | 74 | 58.2 ± 10 | NA | Case: CAD Control: non-CAD | 1 | J 774 | 3 H-C | ABDS |
 Cahill L [32], 2019 | USA | Case: 696 Control: 701 | 100 | 40–75 | 17 | Case: CAD Control: non-CAD | 1 | J 774 | 3 H-C | ABDP |
 Ishikawa T [33], 2015 | Japan | Case: 182 Control: 72 | 81.9 | 66.2 ± 10.3 | 2 | Case: CAD Control: non-CAD | 1 | J 774 | 3 H-C | ABDS |
 Luo M [38], 2018 | China | Case: 120 Control: 90 | 63.6 | 63.96 ± 7.85 | NA | Case: CAD Control: non-CAD | 1 | THP-1 monocytes | 3 H-C | ABDP |
 Khera A [21], 2011 | USA | Case: 442 Control: 351 | 68.6 | 57 ± 9 | NA | Case: CAD Control: non-CAD | 1 | J 774 | 3 H-C | ABDS |
 Wang G [45], 2018 | China | Case: 40 Control: 40 | 62.5 | 30–75 | 2 | Case: CAD Control: non-CAD | 1 | J 774 | 3 H-C | ABDS |
 Shao B [43], 2014 | China | Case: 20 Control: 20 | 70 | 64 ± 11 | 10 months | Case: CAD Control: non-CAD | 1 | BHK | 3 H-C | UCH |
 Luo M [37], 2017 | China | Case: 140 Control: 99 | 66.4 | 63.10 ± 8.42 | NA | Case: CAD Control: non-CAD | 1 | THP-1 monocytes | 3 H-C | ABDP |
 Agarwala AP [31], 2015 | USA | Case: 55 Control: 120 | 60 | 64 ± 11 | NA | Case: CAD Control: non-CAD | 1 | J774 | 3 H-C | ABDP ABDS |
 Norimatsu K [39], 2017 | Japan | Case: 58 Control: 146 | 69 | 61–73 | NA | Case: CAD Control: non-CAD | 1 | J 774 | 3 H-C | UCH |