Skip to main content

Table 1 Characteristics of 18 observational studies

From: High-density lipoprotein cholesterol efflux capacity and incidence of coronary artery disease and cardiovascular mortality: a systematic review and meta-analysis

Author, year Country Sample Number Proportion of males (%) Age (years) Follow-up (years) Subjects Endpoints Donor Cell line Labeling of cholesterol Cholesterol acceptor
Cohort studies
 Rohatgi A [22], 2014 USA 132 cases NA 30–65 Median 9.4 Non-CAD 1,2 J 774 BODIPY-C ABDP
 Liu C [36], 2016 China 122 cases NA 40–85 3.8 CAD 2 J 774 BODIPY-C ABDS
 Ritsch A [41], 2020 Austria 448 cases NA 62.8 ± 10.4 Median 9.9 Non-CAD 2 J 774 3 H-C ABDS
 Kuusisto S [34], 2019 UK 574 cases NA 25–74 15 Non-CAD 1 J 774 3 H-C ABDS
Case-control studies
 Saleheen D [42], 2015 USA Case: 1745
Control: 1749
68 40–79 14 Case: CAD
Control: non-CAD
1 J 774 3 H-C ABDS
 Zhang J [46], 2016 China Case: 214
Control:116
78 67 ± 11 1 Case: CAD
Control: non-CAD
1,2 J 774 3 H-C ABDS
 Li XM [35], 2013 China Cohort A: Case 871
Control: 279
Cohort B: Case: 146
Control: 431
67
70
64 ± 11 3 Case: CAD
Control: non-CAD
1 J 774 3 H-C ABDS
 Shea S [44], 2019 USA Case: 270
Control: 270
NA 45–85 10 Case: CAD
Control: non-CAD
1 THP-1 monocytes 3 H-C UCH
 Patel P [40], 2013 USA Case: 23
Control: 46
74 58.2 ± 10 NA Case: CAD
Control: non-CAD
1 J 774 3 H-C ABDS
 Cahill L [32], 2019 USA Case: 696
Control: 701
100 40–75 17 Case: CAD
Control: non-CAD
1 J 774 3 H-C ABDP
 Ishikawa T [33], 2015 Japan Case: 182
Control: 72
81.9 66.2 ± 10.3 2 Case: CAD
Control: non-CAD
1 J 774 3 H-C ABDS
 Luo M [38], 2018 China Case: 120
Control: 90
63.6 63.96 ± 7.85 NA Case: CAD
Control: non-CAD
1 THP-1 monocytes 3 H-C ABDP
 Khera A [21], 2011 USA Case: 442
Control: 351
68.6 57 ± 9 NA Case: CAD
Control: non-CAD
1 J 774 3 H-C ABDS
 Wang G [45], 2018 China Case: 40
Control: 40
62.5 30–75 2 Case: CAD
Control: non-CAD
1 J 774 3 H-C ABDS
 Shao B [43], 2014 China Case: 20
Control: 20
70 64 ± 11 10 months Case: CAD
Control: non-CAD
1 BHK 3 H-C UCH
 Luo M [37], 2017 China Case: 140
Control: 99
66.4 63.10 ± 8.42 NA Case: CAD
Control: non-CAD
1 THP-1 monocytes 3 H-C ABDP
 Agarwala AP [31], 2015 USA Case: 55
Control: 120
60 64 ± 11 NA Case: CAD
Control: non-CAD
1 J774 3 H-C ABDP
ABDS
 Norimatsu K [39], 2017 Japan Case: 58
Control: 146
69 61–73 NA Case: CAD
Control: non-CAD
1 J 774 3 H-C UCH
  1. NA not applicable. CAD Coronary artery diseases, HDL-C high-density lipoprotein cholesterol, BODIPY-C boron dipyrromethene difluoride-cholesterol, ABDP apolipoprotein B–depleted plasma, ABDS apolipoprotein B–depleted serum, CAD coronary artery disease, 3 H-C 3 H-cholesterol, BHK genetically modified baby hamster kidney cells, UCH HDL isolation by ultracentrifugation. 1, CAD incidence. 2, Cardiovascular mortality