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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: MiR-146a-5p, targeting ErbB4, promotes 3T3-L1 preadipocyte differentiation through the ERK1/2/PPAR-γ signaling pathway

Fig. 3

MiR-146a-5p targeted and regulated the expression of ErbB4 in 3T3-L1 cells. A Potential target genes of miR-146a-5p, predicted using the miRDB, miRTarBase, miRWalk and TargetScan online databases. B Expression of ErbB4 during 3T3-L1 cell differentiation. C Binding sites of miR-146a-5p and ErbB4, predicted using the TargetScan database. D, E Expression of ErbB4 in miR-146a-5p–overexpressing and –inhibited 3T3-L1 cells. FH Relative protein levels of ErbB4 in miR-146a-5p–overexpressing and –inhibited 3T3-L1 cells. Data in (B), (D), (E), (G), and (H) are means ± SDs (n = 3). *P < 0.05, **P < 0.01. OC, overexpression control; IC, inhibition control

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