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Fig. 4 | Lipids in Health and Disease

Fig. 4

From: MiR-146a-5p, targeting ErbB4, promotes 3T3-L1 preadipocyte differentiation through the ERK1/2/PPAR-γ signaling pathway

Fig. 4

MiR-146a-5p promoted adipocyte differentiation through the ErbB4/ERK1/2/PPAR-γ signaling pathway. A, B GO (Biological Process) and KEGG enrichment maps of eight predicted target genes of miR-146a-5p. C Oil Red O staining of ErbB4-inhibited and -overexpressing 3T3-L1 cells after differentiation for 12 days (200×). D, E Relative areas of lipid droplets in ErbB4-inhibited and -overexpressing 3T3-L1 cells after differentiation for 12 days. F, G Intercellular TG contents of ErbB4-inhibited and -overexpressing 3T3-L1 cells after differentiation for 12 days. H Protein levels of ErbB4/ERK1/2/PPAR-γ signaling pathway components in miR-146a-5p–overexpressing and –inhibited 3T3-L1 cells. I, J Protein levels of ErbB4/ERK1/2/PPAR-γ signaling pathway components in ErbB4-inhibited and -overexpressing 3T3-L1 cells. Data in D–G are means ± SDs (n = 3). *P < 0.05. OC, overexpression control; IC, inhibition control

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Lipids in Health and Disease

ISSN: 1476-511X