From: Management of dyslipidemia after allogeneic hematopoietic stem cell transplantation
 | Study 1 (Ref. 53) | Study 2 (Ref. 24) |
---|---|---|
First author | Yvonne A.Efebera | Mehdi Hamadani |
Journal | Biology of Blood and Marrow Transplantation | Journal of Clinical Oncology |
Study time | Mar 2012-Jan 2014 | Sep 2010-Oct 2012 |
Publication year | 2016 | 2013 |
Number of participants | 50 patient-donor pairs | 30 patient-donor pairs |
Median age | ||
Recipient | 51 | 54.5 |
Donor | 50 | 52.5 |
Control group | Historical control subjects (n = 96) | Historial data from the same institution |
Conditioning regimen | ||
Myeloablative conditioning | Fludarabine/busulfan (15%) TBI/etoposide (10%) TBI/cyclophosphamide (5%) | Busulfan/cyclophosphamide (6.6%) Fludarabine/busulfan (36.6%) |
Reduced-intensity conditioning | Fludarabine/busulfan (65%) Fludarabine/melphalan (5%) | Fludarabine/busulfan (56.6%) |
Diagnosis | AML (30%) NHL + HL (36.6%) MDS (10%) PMF (6.6%) Others (16.6%) | AML (33%) NHL + HL (15%) ALL (15%) CML(8%) MDS/CMML (18%) Others (13%) |
GVHD prophylaxis | Methotrexate and tacrolimus | Methotrexate and tacrolimus |
Median CD34 + cell infused (× 106 /kg) | 5.90 | 4.25 |
Median CD3 + cells infused (× 108 /kg) | 2.65 | 3.30 |
Dose of atorvastatin | 40Â mg/day | 40Â mg/day |
Timing of atorvastatin application (before stem cell collection) | 14Â days | Range from 14 to 28Â days |
Infection | CMV, EBV, BKV, fungal and bacterial infections did not differ significantly from the controls | Three patients (10%) developed CMV reactivation and BK-viral hemorrhagic cystitis |
Immune reconstitution | NK and Treg cells were fewer than the control | No statistical significance |
Cytokines | Elevation of RANTES | Elevation of IL-10 |
Grades 2–4 GVHD at + 100 and + 180 days (%) | 30% and 40%, respectively | 3.3% and 11.1%, respectively |
Gades 2–4 GVHD in control group at + 100 days (%) | 28% | Ranged from 30 to 35% |
1Â year NRM (%) | 5.5% | 9.8% |
1Â year PFS (%) | 54% | 65% |
1Â year OS (%) | 82% | 74% |
Conclusion | Negative result | Positive result |