Table 1 Baseline characteristics of the study participants
Mutation-carrying HeFH relatives (n = 117) | Nonmutation-carrying HeFH relatives (n = 104) | General Population Comparison Cohort (n = 2,207) | Probands (n = 32) | |
|---|---|---|---|---|
Sex | ||||
Male | 56 (47.9) | 46 (44.2) | 1019 (46.1) | 14 (43.8) |
Birth-year group, y | ||||
Before 1930 | 13 (11.1) | 12 (11.5) | 249 (11.2) | 8 (25.0) |
1930–1939 | 17 (14.5) | 12 (11.5) | 289 (13.1) | 6 (18.8) |
1940–1949 | 13 (11.1) | 16 (15.4) | 290 (13.1) | 7 (21.8) |
1950–1959 | 24 (20.5) | 23 (22.1) | 470 (21.3) | 5 (15.6) |
1969–1969 | 27 (23.1) | 22 (21.2) | 489 (22.2) | 6 (18.8) |
After 1969 | 23 (19.7) | 19 (18.3) | 420 (19.0) | 0 (0) |
Median follow-up time (IQR)a | 25.6 (20.3–28.0) | 27.0 (24.1–27.3) | 26.0 (18.4–27.0) | 23.2 (15.9–28.0) |
Median blood levels, mmol/L (IQR) | ||||
TC | 9.67 (8.30–11.1) | 5.56 (4.90–6.55) | ⋅⋅⋅ | 11.6 (10.2–12.4) |
HDL-C | 1.13 (0.96–1.41) | 1.32 (1.10–1.61) | ⋅⋅⋅ | 1.28 (0.99–1.54) |
LDL-C | 7.75 (6.55–9.20) | 3.45 (3.00–4.40) | ⋅⋅⋅ | 9.45 (7.90–10.4) |
Tg | 1.31 (0.98–1.90) | 1.20 (0.88–1.84) | ⋅⋅⋅ | 1.20 (1.00–1.80) |