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Table 1 Characteristic of T2DM patients with and without CAD

From: Circulating growth differentiation factor 15 levels and apolipoprotein B to apolipoprotein A1 ratio in coronary artery disease patients with type 2 diabetes mellitus

Characteristic

T2DM without CAD(n = 249)

T2DM with CAD(n = 253)

p value

Clinical variables

 Age (years)

51(42,59)

59(53,67)

< 0.001

 Male (%)

54.15

48.19

0.182

 Diabetic durations (years)

1(0,4)

3(0,6)

< 0.001

 BMI

24.04 ± 0.11

24.93 ± 0.14

0.002

Medical history (n, %)

 Smoking (%)

20.95

18.07

0.432

 Alcohol drinking (%)

14.22

13.65

0.853

 Hypertension (%)

32.41

28.92

0.396

Medication (n, %)

 Insulin (%)

62.06

69.48

0.080

 Metformin (%)

47.04

50.60

0.424

 Anti-hypertension

28.85

23.69

0.189

Laboratory variables

 WBC (×  109/L)

6.09(5.18,7.02)

7.31(5.95,8.64)

< 0.001

 NEU (× 109/L)

3.30(2.66,4.07)

4.53(3.02,6.07)

< 0.001

 LYM (× 109/L)

1.95(1.55,2.39)

1.73(1.28,2.15)

< 0.001

 NLR ratio

1.66(1.30,2.15)

2.50(1.61,4.24)

< 0.001

 hsCRP (mg/dl)

0.80(0.34,2.56)

1.69(0.64,3.74)

< 0.001

 HbA1c (%)

8.5(6.8,10,4)

8.8(7.5,9.0)

0.334

 FPG (mmol/L)

9.76(7.03,12.22)

9.04(7.52,11.45)

0.569

 2hPG (mmol/L)

14.37(10.99,18.81)

18.31(13.22,21.82)

< 0.001

 GA (g/L)

9.54(6.86, 12.30)

10.76(8.97,12.74)

< 0.001

 GA/ALB (%)

0.234(0.174,0.299)

0.354(0.307,0.407)

< 0.001

 ALT (U/L)

19(14,28)

21(15.29)

0.065

 AST (U/L)

17(13,22)

21(16.27)

< 0.001

 GGT (U/L)

27(18,32)

28(19,36)

0.968

 Urea (mmol/L)

5.44(4.50,6.35)

5.88(4.75,7.08)

< 0.001

 Cr (μmol/L)

64(57,72)

73(64,82)

< 0.001

 UA (μmol/L)

350(288,423)

342(286,423)

0.614

 eGFR (ml/min/1.73m2)

108.35(98.77,116.57)

97.63(90.48,106.22)

< 0.001

 FFA (mmol/L)

0.31(0.20,0.45)

0.54(0.34,0.91)

< 0.001

 TC (mmol/L)

4.56(3.86,5.17)

4.47(3.79,5.31)

0.909

 TG (mmol/L)

1.60(1.12,2.87)

1.56(1.02,2.30)

0.135

 HDL-C (mmol/L)

0.96(0.82,1.17)

0.89(0.77,1.07)

0.002

 LDL-C (mmol/L)

2.53(1.91,3.22)

2.40(1.68,3.23)

0.347

 Apo A1 (g/L)

1.22(1.09,1.35)

1.17(1.05,1.28)

0.003

 Apo B (g/L)

0.82(0.69,0.95)

0.90(0.74,1.02)

< 0.001

 Apo B/Apo A1 ratio

0.68(0.55,0.81)

0.78(0.60,0.91)

0.001

 GDF-15 (pg/dl)

7.88(5.92,10.11)

13.84(9.43,18.41)

< 0.001

  1. All data are given in the form of mean ± standard deviation, median (25th percentile-75th percentile) and percentage
  2. Abbreviations: BMI body mass index, WBC white blood cell, NEU neutrophil, LYM lymphocyte, NLR neutrophil to lymphocyte ratios, hs-CRP high-sensitivity C-reactive protein, HbA1c glycated hemoglobin A1c, FPG fasting plasma glucose, 2hPG 2 h-plasma glucose, GA glycated albumin, GA/ALB glycated albumin ratio, ALT alanine aminotransferase, AST aspartate aminotransferase, GGT γ-glutamyl transpeptidase, Cr creatinine, UA uric acid, eGFR estimated glomerular filtration rate (mL/min/1.73 m2), FFA free fatty acid, TC total cholesterol, TG triglyceride, HDL-c high-density lipoprotein cholesterol, LDL-c low-density lipoprotein cholesterol, Apo A1 apolipoproteins A1, Apo B apolipoproteins B, GDF15 growth differentiation factor 15