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Table 3 Associated factors of advanced PNENs (Ki67 index > 55% or NEC G3)

From: The associations between serum high-density lipoprotein cholesterol levels and malignant behavior in pancreatic neuroendocrine neoplasms

Variables Ki67 index > 55% NEC G3a
Univariate
OR (95%CI)
p Multivariate
OR (95%CI)
p Univariate
OR (95%CI)
p Multivariate
OR (95%CI)
p
Age (year) 1.07 (1.02–1.12) 0.031 1.09 (1.03–1.14) < 0.01 1.05 (1.02–1.09) 0.01 1.06 (1.02–1.11) < 0.01
Tumor size (cm) 1.25 (1.03–1.53) 0.33 1.36 (1.06–1.74) 0.21 1.30 (1.10–1.53) 0.33 1.36 (1.12–1.65) < 0.01
HDL-c (mmol/L) 0.19 (0.05–0.80) 0.023 0.10 (0.02–0.51) 0.01 0.27 (0.08–0.93) 0.04 0.21 (0.06–0.80) 0.02
Glucose level (mmol/L) 1.07 (0.88–1.32) 0.49 0.99 (0.77–1.27) 0.99 1.06 (0.88–1.28) 0.56 0.98 (0.79–1.22) 0.84
Vascular invasion 3.96 (1.41–11.09) 0.02 3.58 (1.14–11.21) 0.040 2.31 (0.87–6.14) 0.09 1.82 (0.63–5.26) 0.27
  1. CI Confidence interval, PNENs Pancreatic neuroendocrine neoplasms, NEC Neuroendocrine carcinoma
  2. an = 185 (G1 = 66, G2 = 85, NET G3 = 6, NEC G3 = 28)