Table 3 Associated factors of advanced PNENs (Ki67 index > 55% or NEC G3)

Age (year)

1.07 (1.02–1.12)

0.031

1.09 (1.03–1.14)

< 0.01

1.05 (1.02–1.09)

0.01

1.06 (1.02–1.11)

< 0.01

Tumor size (cm)

1.25 (1.03–1.53)

0.33

1.36 (1.06–1.74)

0.21

1.30 (1.10–1.53)

0.33

1.36 (1.12–1.65)

< 0.01

HDL-c (mmol/L)

0.19 (0.05–0.80)

0.023

0.10 (0.02–0.51)

0.01

0.27 (0.08–0.93)

0.04

0.21 (0.06–0.80)

0.02

Glucose level (mmol/L)

1.07 (0.88–1.32)

0.49

0.99 (0.77–1.27)

0.99

1.06 (0.88–1.28)

0.56

0.98 (0.79–1.22)

0.84

Vascular invasion

3.96 (1.41–11.09)

0.02

3.58 (1.14–11.21)

0.040

2.31 (0.87–6.14)

0.09

1.82 (0.63–5.26)

0.27