Skip to main content
Fig. 2 | Lipids in Health and Disease

Fig. 2

From: Apolipoprotein A5 ameliorates MCT induced pulmonary hypertension by inhibiting ER stress in a GRP78 dependent mechanism

Fig. 2

ApoA5 overexpression inhibiting pulmonary artery remodeling. A H&E staining and immunohistochemical staining of α-smooth muscle actin (α-SMA) showed ApoA5 inhibit the pulmonary artery remodeling. B, C) ApoA5 significantly alleviates MCT induced medial wall thickness and muscularization of small arteries. (B) Quantification of medial wall thickness; (C) Quantification of vessel muscularization; (D) Representative IF staining for Ki67 and α-SMA. For H&E, IHC and IF staining, Scale bar = 50 μm; For medial wall thickness and muscularization quantification, data presented as mean ± SEM, n = 3–4 for all groups. Only vessels with diameter between 30 and 100 μm were analyzed. NM, non-muscularized vessels; PM, partial muscularized vessels; FM, full muscularized vessels. ** Compared with Control group, P < 0.01; *** Compared with Control group, P < 0.001; ## Compared with MCT + GFP group, P < 0.01; ### Compared with MCT + GFP group, P < 0.001

Back to article page