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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: Apolipoprotein A5 ameliorates MCT induced pulmonary hypertension by inhibiting ER stress in a GRP78 dependent mechanism

Fig. 5

ApoA5 interacts with GRP78 to reduce PDGF-BB induced PASMC proliferation and ER stress. A, B co-IP A and immunofluorescence B showing the interacts between ApoA5 and GRP78. C-E Represent staining C and quantification E of EdU incorporation assay and CCK8 assay D showing that blocking the GRP78 by siRNA reversed the proliferation inhibition effect of ApoA5. (F) Represented western blot and quantification G-K) showing blocking the GRP78 by siRNA reversed effect of ApoA5 on ER stress. All data presented as Mean ± SD. For IF staining, Scale bar = 10 μm; *** P < 0.001 compared with control group; ** P < 0.01 compared with control group; * P < 0.05 compared with control group; ### P < 0.001 compared with PDGF-BB + GFP group; ## P < 0.01 compared with PDGF-BB + GFP group; # P < 0.05 compared with PDGF-BB + GFP group; &&& P < 0.001 compared with PDGF-BB + APOA5 + Scramble group; && P < 0.01 compared with PDGF-BB + APOA5 + Scramble group; & P < 0.05 compared with PDGF-BB + APOA5 + Scramble group

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Lipids in Health and Disease

ISSN: 1476-511X