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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Syntaxin interacts with arachidonic acid to prevent diabetes mellitus

Fig. 1

Effect of GLA, AA and LXA4 on STZ-induced cytotoxicity to RIN (rat insulinoma) cells in vitro. Studies were done using both pre-treatment (where RIN cells were pre-treated with GLA, AA and LXA4) and then exposed to STZ; and simultaneous treatment schedule (where RIN cells were exposed to both STZ and lipids at the same time). AA is effective in both pre-treatment and simultaneous schedules whereas GLA is more effective in pre-treatment schedule (but is still less effective than AA). It is seen from these results that AA is more potent than GLA in preventing apoptosis induced by STZ. LXA4 is almost equally effective in preventing STZ-induced apoptosis of RIN cells in both pre-treatment and simultaneous treatment schedules. This data is taken from reference 5. STZ = Streptozotocin; GLA = Gamma-linolenic acid; AA = Arachidonic acid); LXA4 = Lipoxin A4

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