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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: Syntaxin interacts with arachidonic acid to prevent diabetes mellitus

Fig. 3

a Scheme showing how PUFAs (especially AA and DHA; AA > DHA) interact with syntaxin to regulate exocytosis. PUFAs = Polyunsaturated fatty acids. SNARE complex = The core SNARE complex is a 4-α-helix bundle. Synaptobrevin and syntaxin contribute one α-helix each, while SNAP-25 participates with two α-helices (abbreviated as Sn1 and Sn2). The interacting amino acid residues that zip the SNARE complex can be grouped into layers. Each layer has 4 amino acid residues – one residue per each of the 4α-helices. In the center of the complex is the zero ionic layer composed of one arginine (R) and three glutamine (Q) residues, and it is flanked by leucine zippering. Layers '-1', ' + 1' and ' + 2' at the centre of the complex most closely follow ideal leucine-zipper geometry and amino acid composition. b Depiction of the formation of a trans-SNARE complex. Shows how Munc18 interacts with the SNARE proteins during complex formation

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