Table 1 Biochemical indicators of patients (blood lipids, liver function and blood sugar), B-ultrasound, TCM symptom and signs score before treatment (baseline) and after 16 weeks of treatment
From: Danshao Shugan Granule therapy for non-alcoholic fatty liver disease
Ros | Sil | DSSG | P-value among three groups | DSSG + Sil | P-value (Sil vs DSSG + Sil) | P-value (DSSG vs DSSG + Sil) | ||
|---|---|---|---|---|---|---|---|---|
Number | 30 | 50 | 130 | 50 | ||||
TC (mmol/L) | Pre- treatment | 6.55 ± 0.19 | 6.56 ± 0.28 | 6.46 ± 0.55 | 0.340 | 6.50 ± 0.46 | > 0.05 | > 0.05 |
Post treatment | 5.85 ± 0.15 | 6.41 ± 0.23 | 4.97 ± 0.33 | 6.02 ± 0.28 | ||||
Δ | -0.69 ± 0.29 | -0.15 ± 0.29 | -1.56 ± 0.95 | < 0.05 | -0.48 ± 0.41 | > 0.05 | < 0.05 | |
TG (mmol/L) | Pre- treatment | 2.83 ± 0.13 | 2.80 ± 0.59 | 2.72 ± 0.90 | 0.695 | 3.03 ± 0.71 | > 0.05 | > 0.05 |
Post treatment | 2.26 ± 0.09 | 2.32 ± 0.51 | 1.80 ± 0.24 | 2.30 ± 0.41 | ||||
Δ | -0.57 ± 0.60 | -0.48 ± 0.67 | -0.99 ± 1.09 | < 0.05 | -0.73 ± 0.68 | > 0.05 | > 0.05 | |
ALT (U/L) | Pre- treatment | 76.84 ± 3.51 | 75.41 ± 6.99 | 74.98 ± 16.39 | 0.792 | 76.47 ± 8.60 | > 0.05 | > 0.05 |
Post treatment | 71.18 ± 4.12 | 38.96 ± 4.51 | 44.01 ± 6.06 | 36.94 ± 4.01 | ||||
Δ | -5.66 ± 13.37 | -36.45 ± 5.80 | -32.78 ± 25.42 | < 0.05 | -39.53 ± 8.34 | > 0.05 | > 0.05 | |
AST (U/L) | Pre- treatment | 72.42 ± 2.69 | 74.21 ± 8.27 | 73.08 ± 16.16 | 0.822 | 76.99 ± 12.02 | > 0.05 | > 0.05 |
Post treatment | 62.41 ± 2.32 | 54.20 ± 7.73 | 42.24 ± 4.96 | 53.26 ± 8.23 | ||||
Δ | -10.01 ± 17.60 | -20.01 ± 8.84 | -32.02 ± 19.73 | < 0.05 | -23.73 ± 8.31 | > 0.05 | < 0.05 | |
GGT (U/L) | Pre- treatment | 71.02 ± 3.28 | 74.99 ± 9.08 | 76.40 ± 10.64 | < 0.05 | 76.43 ± 9.95 | > 0.05 | > 0.05 |
Post treatment | 47.20 ± 2.54 | 64.26 ± 7.68 | 47.58 ± 6.21 | 60.09 ± 6.30 | ||||
Δ | -23.82 ± 13.97 | -10.72 ± 10.79 | -31.72 ± 18.89 | < 0.05 | -16.34 ± 8.31 | > 0.05 | > 0.05 | |
FPG (mmol/L) | Pre- treatment | 6.09 ± 0.14 | 6.03 ± 0.29 | 5.89 ± 0.72 | 0.139 | 6.02 ± 0.36 | > 0.05 | > 0.05 |
Post treatment | 4.26 ± 0.08 | 5.76 ± 0.29 | 5.52 ± 0.58 | 5.63 ± 0.31 | ||||
Δ | -1.83 ± 1.19 | -0.27 ± 0.28 | -0.36 ± 0.72 | < 0.05 | -0.39 ± 0.36 | > 0.05 | > 0.05 | |
B-ultrasonography | Cure | 4 (13.0%) | 1 (2.0%) | 40 (31.0%) | < 0.05 | 5 (10.0%) | > 0.05 | < 0.05 |
Obviously effective | 12 (40.0%) | 4 (8.0%) | 32 (24.5%) | < 0.05 | 11 (22.0%) | < 0.05 | > 0.05 | |
Effective | 8 (27.0%) | 24 (48.0%) | 47 (36.0%) | 0.139 | 23 (46.0%) | > 0.05 | > 0.05 | |
Non-effective | 6 (20.0%) | 21 (42.0%) | 11 (8.5%) | < 0.05 | 11 (22.0%) | < 0.05 | < 0.05 | |
Effective rate | 24 (80.0%) | 29 (58.0%) | 119 (91.5%) | < 0.05 | 39 (78.0%) | < 0.05 | < 0.05 | |
TCM symptom and signs score | Pre- treatment | 14.00 ± 0.51 | 13.92 ± 2.39 | 13.72 ± 1.10 | 0.529 | 14.76 ± 2.60 | > 0.05 | < 0.05 |
Post treatment | 3.00 ± 0.31 | 9.10 ± 1.95 | 2.41 ± 0.43 | < 0.05 | 5.04 ± 2.27 | < 0.05 | < 0.05 | |
Δ | -11.00 ± 0.20 | -4.82 ± 0.44 | -11.31 ± 0.67 | < 0.05 | -9.72 ± 0.33 | < 0.05 | < 0.05 |