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Table 2 Biochemical indicators (blood lipid, liver function and blood glucose), B-ultrasonography and TCM syndrome scores of three TCM syndromes types (before treatment and 16 weeks after DSSG treatment)

From: Danshao Shugan Granule therapy for non-alcoholic fatty liver disease

  

D1

D2

D3

P-value

Number

 

30

30

30

 

TC (mmol/L)

Pre- treatment

6.52 ± 0.19

6.50 ± 0.19

6.56 ± 0.17

0.439

Post treatment

5.15 ± 0.12

4.61 ± 0.09

4.77 ± 0.11

 
 

Δ

-1.37 ± 0.94

-1.89 ± 0.97

-1.79 ± 0.99

0.093

TG (mmol/L)

Pre- treatment

2.77 ± 0.26

2.72 ± 0.22

2.76 ± 0.14

0.630

Post treatment

1.77 ± 0.07

1.45 ± 0.06

1.66 ± 0.07

 
 

Δ

-1.00 ± 1.13

-1.27 ± 1.17

-1.10 ± 0.69

0.586

ALT (U/L)

Pre- treatment

75.58 ± 6.61

75.82 ± 5.16

77.92 ± 5.10

0.220

Post treatment

43.01 ± 2.41

33.95 ± 0.87

45.32 ± 1.55

 
 

Δ

-32.57 ± 28.86

-41.87 ± 25.43

-32.6 ± 26.26

0.308

AST (U/L)

Pre- treatment

76.93 ± 2.36

76.60 ± 2.85

78.17 ± 3.52

0.100

Post treatment

45.86 ± 1.46

41.04 ± 0.97

43.07 ± 1.44

 
 

Δ

-31.07 ± 11.31

-35.56 ± 14.85

-35.1 ± 18.66

0.458

GGT (U/L)

Pre- treatment

88.10 ± 3.75

86.20 ± 4.72

87.20 ± 3.37

0.190

Post treatment

55.00 ± 1.08

48.51 ± 1.66

48.86 ± 1.87

 
 

Δ

-33.10 ± 18.19

-37.69 ± 18.71

-38.34 ± 14.91

0.447

FPG (mmol/L)

Pre- treatment

5.88 ± 0.18

5.95 ± 0.15

5.86 ± 0.12

0.060

Post treatment

5.70 ± 0.13

5.55 ± 0.13

5.58 ± 0.10

 
 

Δ

-0.18 ± 0.65

-0.40 ± 0.61

-0.28 ± 0.83

0.482

B-ultrasonography

Cure

8 (26.7%)

10 (33.3%)

12 (40.0%)

0.549

 

Obviously effective

11 (36.6%)

7 (23.4%)

6 (20.0%)

0.303

 

Effective

9 (30.0%)

10 (33.3%)

10 (33.3%)

0.950

 

Non-effective

2 (6.7%)

3 (10.0%)

2 (6.7%)

0.857

 

Effective rate

93.3%

90.0%

93.3%

0.857

TCM symptom and signs score

Pre- treatment

14.07 ± 0.45

14.10 ± 0.44

14.20 ± 0.46

0.506

 

Post treatment

2.33 ± 0.26 a

2.13 ± 0.32 b

2.86 ± 0.27 c

 < 0.001

 

Δ

-11.74 ± 0.19 a

-11.97 ± 0.12 b

-11.34 ± 0.19 c

 < 0.001

  1. Note: If the measured data were normally distributed, the mean ± standard deviation (SD) was used. Single factor variance analysis was used to make pairwise comparison among multiple groups. a-c different lower case letters denotes a significant difference at P < 0.05 between the different treatment groups. The test level was α = 0.05 and a P-value < 0.05 was considered to be statistically significant. Δ, value change before and after the rosiglitazone, Silibinin and DSSG treatments for the TCM symptoms and sign scores to compare the TCM syndrome. D1 group, stagnation of liver-QI with deficiency of the spleen and phlegm stagnation; D2 group, phlegm stagnation, blood stasis, heat conversion of the dampness stagnancy; D3 group, damp depression, blood stasis, deficiency of liver-YIN
  2. ALT alanine aminotransferase, AST aspartate amino transferase, DSSG Danshao Shugan Granules, FPG Fasting plasma glucose, GGT γ-glutamyl transpeptidase, TC total cholesterol, TCM traditional Chinese medicine TG triacylglycerol