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Table 2 Biochemical indicators (blood lipid, liver function and blood glucose), B-ultrasonography and TCM syndrome scores of three TCM syndromes types (before treatment and 16 weeks after DSSG treatment)

From: Danshao Shugan Granule therapy for non-alcoholic fatty liver disease

   D1 D2 D3 P-value
Number   30 30 30  
TC (mmol/L) Pre- treatment 6.52 ± 0.19 6.50 ± 0.19 6.56 ± 0.17 0.439
Post treatment 5.15 ± 0.12 4.61 ± 0.09 4.77 ± 0.11  
  Δ -1.37 ± 0.94 -1.89 ± 0.97 -1.79 ± 0.99 0.093
TG (mmol/L) Pre- treatment 2.77 ± 0.26 2.72 ± 0.22 2.76 ± 0.14 0.630
Post treatment 1.77 ± 0.07 1.45 ± 0.06 1.66 ± 0.07  
  Δ -1.00 ± 1.13 -1.27 ± 1.17 -1.10 ± 0.69 0.586
ALT (U/L) Pre- treatment 75.58 ± 6.61 75.82 ± 5.16 77.92 ± 5.10 0.220
Post treatment 43.01 ± 2.41 33.95 ± 0.87 45.32 ± 1.55  
  Δ -32.57 ± 28.86 -41.87 ± 25.43 -32.6 ± 26.26 0.308
AST (U/L) Pre- treatment 76.93 ± 2.36 76.60 ± 2.85 78.17 ± 3.52 0.100
Post treatment 45.86 ± 1.46 41.04 ± 0.97 43.07 ± 1.44  
  Δ -31.07 ± 11.31 -35.56 ± 14.85 -35.1 ± 18.66 0.458
GGT (U/L) Pre- treatment 88.10 ± 3.75 86.20 ± 4.72 87.20 ± 3.37 0.190
Post treatment 55.00 ± 1.08 48.51 ± 1.66 48.86 ± 1.87  
  Δ -33.10 ± 18.19 -37.69 ± 18.71 -38.34 ± 14.91 0.447
FPG (mmol/L) Pre- treatment 5.88 ± 0.18 5.95 ± 0.15 5.86 ± 0.12 0.060
Post treatment 5.70 ± 0.13 5.55 ± 0.13 5.58 ± 0.10  
  Δ -0.18 ± 0.65 -0.40 ± 0.61 -0.28 ± 0.83 0.482
B-ultrasonography Cure 8 (26.7%) 10 (33.3%) 12 (40.0%) 0.549
  Obviously effective 11 (36.6%) 7 (23.4%) 6 (20.0%) 0.303
  Effective 9 (30.0%) 10 (33.3%) 10 (33.3%) 0.950
  Non-effective 2 (6.7%) 3 (10.0%) 2 (6.7%) 0.857
  Effective rate 93.3% 90.0% 93.3% 0.857
TCM symptom and signs score Pre- treatment 14.07 ± 0.45 14.10 ± 0.44 14.20 ± 0.46 0.506
  Post treatment 2.33 ± 0.26 a 2.13 ± 0.32 b 2.86 ± 0.27 c  < 0.001
  Δ -11.74 ± 0.19 a -11.97 ± 0.12 b -11.34 ± 0.19 c  < 0.001
  1. Note: If the measured data were normally distributed, the mean ± standard deviation (SD) was used. Single factor variance analysis was used to make pairwise comparison among multiple groups. a-c different lower case letters denotes a significant difference at P < 0.05 between the different treatment groups. The test level was α = 0.05 and a P-value < 0.05 was considered to be statistically significant. Δ, value change before and after the rosiglitazone, Silibinin and DSSG treatments for the TCM symptoms and sign scores to compare the TCM syndrome. D1 group, stagnation of liver-QI with deficiency of the spleen and phlegm stagnation; D2 group, phlegm stagnation, blood stasis, heat conversion of the dampness stagnancy; D3 group, damp depression, blood stasis, deficiency of liver-YIN
  2. ALT alanine aminotransferase, AST aspartate amino transferase, DSSG Danshao Shugan Granules, FPG Fasting plasma glucose, GGT γ-glutamyl transpeptidase, TC total cholesterol, TCM traditional Chinese medicine TG triacylglycerol