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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Anthracycline-induced cardiotoxicity: targeting high-density lipoproteins to limit the damage?

Fig. 1

Proposed mechanism depicting the role of HDL in doxorubicin-induced cardiac toxicity. We propose that a shift in high-density lipoproteins (HDL) subclasses in breast cancer patients treated with doxorubicin leads to dysfunctional HDL with reduced anti-oxidative, anti-inflammatory, reverse cholesterol transport function and anti-apoptotic function that may facilitate the cardiac damage associated with the treatment of doxorubicin

Abbreviations: ApoA1 Apolipoprotein A1, CE Cholesteryl ester, DOX Doxorubicin, FC Free cholesterol, HDL High-density lipoprotein, LCAT Lecithin cholesterol acyltransferase, PON1 Paraoxonase 1, S1P Sphingosine-1-phosphate, TG Triglyceride

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