Table 1 Cytotoxicity of EPL, PPC and PI in the HepG2 cell line
Cell viability (% of untreated cells) | EPL concentration mg/ml | ||||||||
0 | 0.0075 | 0.0375 | 0.075 | 0.375 | 0.75 | 3.75 | 7.5 | 37.5 | |
Mean (SD) [range] | 97.25 (0.69) [96.7–98.0] | 96.08 (10.87) [86.7–105.7] | 97.08 (5.49) [92.3–102.0] | 96.17 (5.39) [91.3–101.0] | 71.75 (1.55) [70.3–73.7] | 47.83 (0.88) [47.0–49.0] | 23.42 (0.74) [22.7–24.3] | 24.67 (0.98) [23.3–25.7] | 4.08 (0.69) [3.3–4.7] |
PPC concentration mg/ml | |||||||||
0 | 0.009 | 0.045 | 0.09 | 0.45 | 0.9 | 4.5 | 8.9 | 44.5 | |
Mean (SD) [range] | 100.17 (1.04) [99.0–101.3] | 102.58 (3.84) [98.3–107.0] | 102.17 (4.24) [97.7–107.3] | 99.50 (5.01) [95.0–106.7] | 93.00 (3.14) [91.0–97.7] | 90.08 (4.47) [86.0–95.7] | 81.58 (4.13) [75.7–85.0] | 76.67 (5.13) [70.3–81.0] | 63.25 (9.87) [49.0–70.7] |
PI concentration mg/ml | |||||||||
0 | 0.0073 | 0.036 | 0.073 | 0.36 | 0.73 | 3.6 | 7.3 | 36.3 | |
Mean (SD) [range] | 100.17 (1.04) [99.0–101.3] | 93.17 (8.46) [84.3–101.7] | 93.33 (8.54) [86.3–105.7] | 92.33 (6.32) [84.7–99.0] | 84.08 (3.56) [79.7–88.3] | 78.75 (3.40) [74.7–82.7] | 75.17 (2.73) [72.7–79.0] | 60.33 (6.31) [55.3–69.3] | 3.00 (0.47) [2.7–3.7] |