Fig. 2

RNA-seq analysis of liver sections of the chronic-binge ApoH^−/− mouse model. A, B ApoH mRNA levels assayed using qPCR; *P < 0.05, ***P < 0.001. C Venn map showing the extent of gene expression in the four different groups. D The number of differentially expressed genes in WT and ApoH^−/− mice and their alcohol-fed counterparts. E Volcano plot showing the DEGs in WT and ApoH^−/− mice. F KEGG pathways analysis depicting gene richness in ApoH^−/− mice compared with that in the WT control group. G Volcano plots of the DEGs in WT and ApoH^−/− mice fed alcohol. H Bubble diagram representing gene abundance in alcohol-fed mice, including ApoH^−/− mice, versus the WT control group, using KEGG pathways analysis