Fig. 3

Differential gene expression obtained via RNA-seq data. A Number of DEGs between control-fed WT and ApoH^−/− mice and their alcohol-fed counterparts, and the relationship between them. B Heatmap representing the 19 common DEGs between the compared groups. C DEGs abundance in ApoH^−/− mice versus the WT control group analyzed using KEGG pathways. D Heatmap representing the 28 DEGs between WT and ApoH^−/− mice post alcohol feeding. E Column diagram representing the abundance of DEGs in alcohol-fed and control ApoH^−/− as well as WT groups analyzed using KEGG pathways. F Relative expression of genes involved in regulating CYP450 enzymes in WT and ApoH^−/− mice given alcohol and control diets. Values are represented as the mean ± SEM (n = 3). *P < 0.05