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Fig. 6 | Lipids in Health and Disease

Fig. 6

From: Replacing saturated fatty acids with polyunsaturated fatty acids increases the abundance of Lachnospiraceae and is associated with reduced total cholesterol levels—a randomized controlled trial in healthy individuals

Fig. 6

A graphic illustration of the hypothetical mechanisms related to fat quality, gut microbiota, and circulating cholesterol as outlined in the discussion. Replacing SFAs with PUFAs for three days did not affect the levels of bile acids and SCFAs in the circulation. However, gut bacteria may convert cholesterol in the intestine to coprostanol, which is secreted in feces, and hence the circulating levels of cholesterol will decrease. The figure was created with BioRender.com. Abbreviations: PUFAs: polyunsaturated fatty acids, SCFAs: short-chain fatty acids, SFAs: saturated fatty acids

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Lipids in Health and Disease

ISSN: 1476-511X