Table 1 Baseline characteristics of the sample, total and according to familial hypercholesterolemia phenotype based on adjusted DLCNa criteria
DLCNa criteria for phenotypical FH | |||||
|---|---|---|---|---|---|
total N = 838 | unlikely FH n = 661 | possible FH n = 140 | probable FH n = 26 | definite FH n = 11 | |
Male sex | 590 (70.4) | 469 (71) | 96 (68.6) | 18(69.2) | 7 (63.6) |
Female sex | 248 (29.6) | 192 (29) | 44 (31.4) | 8 (30.8) | 4 (36.4) |
Age, years | 69 ± 11.0 | 71 ± 10.3 | 64 ± 11.8 | 59 ± 10.9 | 70 ± 10.2 |
European ancestry | 822 (98.1) | 650 (98.3) | 135 (96.4) | 26 (100) | 11 (100) |
History of CAD | 431 (51.4) | 332 (48.9) | 85 (60.7) | 16 (61.5) | 7 (63.6) |
History of myocardial infarction | 262 (31.3) | 185 (28.0) | 62 (44.3) | 10 (38.5) | 5 (45.5) |
History of bypass surgery | 65 (7.8) | 50 (7.6) | 14 (10) | 1 (3.8) | 0 (0) |
Total obstructive CAD (new cases and previously established cases) | 599 (71.5) | 458 (69.3) | 109 (77.9) | 21 (80.8) | 11 (100) |
One vessel disease | 132 (15.8) | 102 (15.4) | 24 (17.1) | 3 (11.5) | 3 (27.3) |
Two vessel disease | 202 (24.1) | 152 (23.0) | 37 (26.4) | 8 (30.8) | 5 (45.5) |
Three vessel disease | 265 (31.6) | 204 (30.9) | 48 (34.3) | 10 (38.5) | 3 (27.3) |
Non-obstructive CAD | 104 (12.4) | 88 (13.3) | 14 (10) | 2 (7.7) | 0 (0) |
No apparent CAD | 135 (16.1) | 115 (17.4) | 17 (12.1) | 3 (11.5) | 0 (0) |
History of cerebrovascular event | 94 (11.2) | 74 (11.2) | 13 (9.3) | 7 (26.9) | 0 (0) |
Type 2 Diabetes | 231 (27.6) | 187 (28.3) | 34 (24.3) | 6 (23.1) | 4 (36.4) |
Hypertension | 678 (80.9) | 539 (81.5) | 109 (77.9) | 21 (80.8) | 9 (81.8) |
Current smoking | 156 (18.7) | 95 (14.4) | 44 (31.4) | 12 (46.2) | 5 (45.5) |
Pack Years | 30 ± 28.3 | 30 ± 28.9 | 30 ± 26.5 | 26 ± 17.4 | 34 ± 44.8 |
Obesity | 216 (25.9) | 160 (24.3) | 47 (33.6) | 7 (26.9) | 2 (20) |
BMI (kg/m2) | 28 ± 4.9 | 28 ± 4.9 | 28 ± 5.2 | 28 ± 4.7 | 26 ± 4.2 |
Systolic blood pressure (mmHg) | 135 ± 20.8 | 135 ± 21.0 | 133 ± 19.5 | 133 ± 22 | 150 ± 20.5 |
Diastolic blood pressure (mmHg) | 78 ± 12.5 | 78 ± 12.9 | 78 ± 11.4 | 83 ± 13.3 | 85 ± 9.8 |