Fig. 6
From: FGF15 promotes hepatic NPC1L1 degradation in lithogenic diet-fed mice
FGF15-FGFR4 pathway decreased liver cholesterol infiltration and fibrosis. The WT mice were fed with 8-week HFCD or LD. The mNPC1L1hepatic-OE mice were fed with 8-week HFCD with or without FGF15 treatment, and LD with or without H3B-6527 treatment prior to the indicated experiments. A Masson staining of liver fibrosis in mice. The arrowhead pointed to the noticeable portion of perisinusoidal fibrosis, portal fibrosis, plus bridging fibrosis. Original magnification, × 10 and × 40. B HE staining of liver sections from mice. The arrowhead pointed to the noticeable portion of hepatocyte ballooning and the arrow pointed to the mallory-denk bodies. Original magnification, × 10 and × 40. C Fibrosis scores and steatosis scores in mice. *P < 0.05, **P < 0.01, ns no significance. HFCD, high fat-cholesterol diet; LD, lithogenic diet