Fig. 10From: WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCCSchematic illustration of the activity of WY-14,643 in ccRCC. WY-14,643 upregulates CPT1A by recognizing and activating PPARα and inhibiting the NF-κB signaling, and then promotes FAO in the mitochondrion, followed by decomposition of lipid dropletsBack to article page