Table 1 Baseline characteristics of the study population grouped by age-stratified quartiles of the CERAD total score

Age, yrs^a

69.1 ± 6.5

69.6 ± 7.4

69.3 ± 6.3

68.8 ± 6.3

68.6 ± 6.9

 < 0.001

Gender, n(%)^c

 Female

705(55)

184(12)

197(14)

178(16)

146(14)

 < 0.001

 Male

672(45)

274(14)

184(13)

127(9.4)

87(7.5)

Race, n(%)^c

 White

696(79)

180(18)

185(21)

171(21)

160(19)

 < 0.001

 Black

281(8.5)

110(3)

83(2.6)

57(1.8)

31(1)

 Other races

400(12)

168(4.8)

113(3.6)

77(2.4)

42(1.2)

Education level, n(%)^c

 Less than high school

356(16)

183(7.5)

110(5.4)

45(2.3)

18(1.1)

 < 0.001

 High school graduate

329(23)

113(6.8)

94(6.8)

72(5.5)

50(3.9)

 College or above

690(61)

161(11)

176(15)

188(17)

165(16)

Marital status, n(%)^c

 Married/Cohabiting

855(68)

294(18)

225(19)

190(17)

146(15)

 < 0.001

 Not married/Never married

522(32)

164(8)

156(9.2)

115(8.1)

87(6.3)

BMI, n(%)^c

 Normal

379(27)

122(6.3)

98(6.6)

88(7.2)

71(7.1)

 < 0.001

 Overweight

465(35)

155(9.3)

128(9.8)

100(8.4)

82(7.1)

 Obese

533(38)

181(10)

155(11)

117(9.4)

80(7.4)

Drinking status, n(%)^c

 Lifetime abstainer

215(14)

68(3.3)

69(4)

45(3.4)

33(2.8)

 < 0.001

 Former drinker

368(23)

136(7.4)

109(6.8)

77(5.2)

46(3.7)

 Current drinker

766(63)

239(15)

195(17)

180(16)

152(15)

Smoking status, n(%)^c

 Never smoker

682(49)

222(12)

179(13)

149(12)

132(12)

 < 0.001

 Former smoker

527(40)

173(10)

154(12)

122(11)

78(7.2)

 Current smoker

166(11)

63(3.7)

46(2.7)

34(2.5)

23(1.9)

 Diabetes, n(%)^c

302(19)

108(6.3)

99(6.2)

61(3.7)

34(2.5)

 < 0.001

 Hypertension, n(%)^c

859(59)

290(16)

241(17)

189(14)

139(12)

 < 0.001

 Stroke, n(%)^c

99(6.7)

35(2)

34(2)

15(1.3)

15(1.4)

 < 0.001

Statin use, n(%)^c

 Statin user

850(60)

276(14)

223(16)

195(15)

156(15)

 < 0.001

 Non statin user

527(40)

182(12)

158(12)

110(9.6)

77(6.5)

 TC, mmol/L^a

4.97 ± 1.07

4.77 ± 1.12

4.91 ± 1.02

5.08 ± 1.07

5.17 ± 0.99

 < 0.001

 LDL-C, mmol/L ^a

2.87 ± 0.93

2.73 ± 1.00

2.81 ± 0.89

2.95 ± 0.91

3.02 ± 0.85

 < 0.001

 HDL-C, mmol/L ^a

1.47 ± 0.43

1.38 ± 0.45

1.46 ± 0.38

1.54 ± 0.41

1.54 ± 0.42

 < 0.001

 TG, mmol/L ^b

1.19 (0.85,1.71)

1.38 (0.90,1.75)

1.21 (0.89,1.75)

1.12 (0.78,1.64)

1.10 (0.81,1.68)

 < 0.001

 RC, mmol/L ^b

0.54 (0.39,0.78)

0.63 (0.41,0.81)

0.55 (0.41,0.80)

0.51 (0.36,0.75)

0.50 (0.36,0.77)

 < 0.001