Table 5 Sensitivity analyses of the relationship between CAD risk and traditional cardio-metabolic factors, atherogenicity indices, and surrogate markers of insulin resistance excluding those with diabetes

Serum traditional cardio-metabolic parameters (mmol/L)

 Triglyceride

  Continuous ^a

2.22 (1.80–2.74)

 < 0.001

  Adjusted model ^a

1.00

1.46

(0.97–2.20)

1.92

(1.28–2.88)

3.17

(2.13–4.72)

 Total cholesterol

  Continuous ^a

1.38 (1.21–1.58)

 < 0.001

  Adjusted model ^a

1.00

1.34

(0.91–1.98)

1.17

(0.77–1.78)

1.80

(1.23–2.62)

 Low-density lipoprotein-cholesterol (LDL-C)

  Continuous ^a

1.44 (1.25–1.66)

 < 0.001

  Adjusted model ^a

1.00

0.57

(0.38–0.85)

0.86

(0.57–1.30)

1.57

(1.10–2.23)

 High-density lipoprotein-cholesterol (HDL-C)

  Continuous ^a

0.22 (0.13–0.38)

 < 0.001

  Adjusted model ^a

1.00

0.82

(0.56–1.19)

0.70

(0.49–0.99)

0.37

(0.25–0.54)

 Fasting blood sugar

  Continuous ^a

2.72 (2.31–3.22)

 < 0.001

  Adjusted model ^a

1.00

2.70

(1.55–4.68)

4.47

(2.68–7.44)

21.00

(12.98–33.98)

Novel indices

 Atherogenic index of plasma (AIP)

  Continuous ^a

11.88 (6.50–21.71)

 < 0.001

  Adjusted model ^a

1.00

2.06

(1.35–3.15)

2.87

(1.89–4.37)

4.17

(2.74–6.34)

 Castelli risk index-I (CRI-I)

  Continuous ^a

1.44 (1.32–1.58)

 < 0.001

  Adjusted model ^a

1.00

1.79

(1.19–2.68)

1.93

(1.27–2.92)

3.27

(2.20–4.87)

 Castelli risk index-II (CRI-II)

  Continuous ^a

1.51 (1.35–1.68)

 < 0.001

  Adjusted model ^a

1.00

1.06

(0.72–1.57)

1.31

(0.87–1.96)

2.12

(1.46–3.09)

 Cholesterol index (CHOLINDEX)

  Continuous ^a

1.54 (1.34–1.77)

 < 0.001

  Adjusted model ^a

1.00

0.70

(0.47–1.05)

1.01

(0.66–1.53)

1.85

(1.28–2.66)

 Lipoprotein combine index (LCI)

  Continuous ^a

1.03 (1.02–1.03)

 < 0.001

  Adjusted model ^a

1.00

2.32

(1.53–3.53)

2.74

(1.80–4.17)

3.87

(2.56–5.85)

 Metabolic score for insulin resistance (METS − IR)

  Continuous ^b

1.00 (0.98–1.02)

0.707

  Adjusted model ^b

1.00

1.40

(0.96–2.04)

1.54

(1.07–2.23)

0.94

(0.64–1.39)

 Triglyceride glucose (TyG) index

  Continuous ^b

4.44 (3.34–5.92)

 < 0.001

  Adjusted model ^b

1.00

1.85

(1.18–2.89)

2.41

(1.56–3.74)

4.87

(3.22–7.35)

 Triglyceride glucose (TyG)-BMI

  Continuous ^b

0.99 (0.98–1.00)

0.531

  Adjusted model ^b

1.00

1.42

(0.97–2.07)

1.38

(0.95–2.00)

0.88

(0.59–1.29)