Table 2 Association of BMI (categorized) and serum lipid level (by quartiles) with lymph node metastasis
Variables | Univariate logistic analysis | Multivariate logistic analysis † | |||
|---|---|---|---|---|---|
OR (95% CI) | P value | OR (95% CI) | P value | P for trend | |
TC (mmol/L) | 0.949 | ||||
Q1 (≤ 3.82) | 1.00 (ref) | 1.00 (ref) | |||
Q2 (3.83–4.43) | 0.77 (0.55–1.08) | 0.131 | 1.48 (0.69–3.18) | 0.310 | |
Q3 (4.44–5.07) | 0.88(0.63–1.24) | 0.463 | 1.17 (0.46–2.99) | 0.741 | |
Q4 (≥ 5.08) | 0.63 (0.45–0.89) | 0.009 | 0.88 (0.26–2.91) | 0.831 | |
TG (mmol/L) | |||||
Q1 (≤ 0.87) | 1.00 (ref) | ||||
Q2 (0.88–1.18) | 1.05 (0.75–1.47) | 0.794 | |||
Q3 (1.19–1.65) | 1.11 (0.79–1.57) | 0.542 | |||
Q4 (≥ 1.66) | 1.09 (0.78–1.54) | 0.603 | |||
HDL-C (mmol/L) | 0.174 | ||||
Q1 (≤ 0.92) | 1.00 (ref) | 1.00 (ref) | |||
Q2 (0.93–1.08) | 0.71 (0.51–1.00) | 0.050 | 0.78 (0.45–1.36) | 0.381 | |
Q3 (1.09–1.27) | 0.62 (0.44–0.88) | 0.007 | 0.75 (0.40–1.43) | 0.385 | |
Q4 (≥ 1.28) | 0.39 (0.27–0.56) | < 0.001 | 0.60 (0.27–1.30) | 0.196 | |
LDL-C (mmol/L) | 0.905 | ||||
Q1 (≤ 2.28) | 1.00 (ref) | 1.00 (ref) | |||
Q2 (2.29–2.76) | 0.79 (0.56–1.11) | 0.182 | 0.71 (0.34–1.47) | 0.351 | |
Q3 (2.77–3.22) | 0.90 (0.64–1.26) | 0.524 | 1.08 (0.44–2.69) | 0.864 | |
Q4 (≥ 3.23) | 0.73 (0.52–1.02) | 0.069 | 1.11 (0.36–3.41) | 0.858 | |
LP (a) (mg/L) | 0.356 | ||||
Q1 (≤ 84) | 1.00 (ref) | 1.00 (ref) | |||
Q2 (85–161) | 1.33 (0.95–1.87) | 0.100 | 1.08 (0.71–1.97) | 0.513 | |
Q3 (162–314) | 1.20 (0.85–1.69) | 0.303 | 0.71 (0.42–1.18) | 0.187 | |
Q4 (≥ 315) | 1.42 (1.01–1.99) | 0.046 | 1.34 (0.79–2.27) | 0.277 | |
THR | 0.977 | ||||
Q1 (≤ 0.74) | 1.00 (ref) | 1.00 (ref) | |||
Q2 (0.75–1.12) | 1.34 (0.95–1.89) | 0.091 | 1.03 (0.60–1.75) | 0.921 | |
Q3 (1.13–1.66) | 1.33 (0.95–1.88) | 0.101 | 0.74 (0.40–1.37) | 0.338 | |
Q4 (≥ 1.67) | 1.72 (1.22–2.42) | 0.002 | 0.78 (0.39–1.56) | 0.482 | |
BMI (kg/m2) | 0.006 | ||||
< 23 | 1.00 (ref) | 1.00 (ref) | |||
23–24.9 | 1.49 (1.11–2.00) | 0.008 | 2.02 (1.26–3.23) | 0.003 | |
≥ 25 | 1.77 (1.32–2.36) | < 0.001 | 1.83 (1.15–2.91) | 0.011 | |
Sex | |||||
Male | 1.00 (ref) | ||||
Female | 1.04 (0.80–1.35) | 0.788 | |||
Age (years) | |||||
≤ 65 | 1.00 (ref) | ||||
> 65 | 1.22 (0.95–1.56) | 0.116 | |||
Location | |||||
Upper | 1.00 (ref) | 1.00 (ref) | |||
Middle | 1.16 (0.86–1.57) | 0.325 | 1.48 (0.92–2.37) | 0.106 | |
Lower | 1.38 (1.02–1.87) | 0.036 | 2.06 (1.28–3.31) | 0.003 | |
Grade ‡ | |||||
G1/G1-2 | 1.00 (ref) | 1.00 (ref) | |||
G2 | 13.60 (3.25–56.89) | < 0.001 | 3.96 (0.51–30.65) | 0.187 | |
G2-3 | 60.18 (14.46–250.44) | < 0.001 | 5.44 (0.69–42.95) | 0.108 | |
G3 | 58.94 (14.26–243.62) | < 0.001 | 5.35 (0.65–43.82) | 0.118 | |
Tumor size (cm) | |||||
≤ 2.5 | 1.00 (ref) | 1.00 (ref) | |||
> 2.5 | 5.41 (4.14–7.06) | < 0.001 | 1.47 (0.97–2.20) | 0.066 | |
T stage | |||||
T1 | 1.00 (ref) | 1.00 (ref) | |||
T2 | 4.37 (2.93–6.51) | < 0.001 | 1.94 (1.16–3.250 | 0.012 | |
T3 | 15.26 (10.68–21.81) | < 0.001 | 4.88 (2.85–8.34) | < 0.001 | |
T4 | 33.12 (19.07–57.53) | < 0.001 | 8.43 (4.06–17.48) | < 0.001 | |
PNI | |||||
Absent | 1.00 (ref) | 1.00 (ref) | |||
Present | 7.63 (5.67–10.27) | < 0.001 | 2.18 (1.39–3.43) | 0.001 | |
LVI | |||||
Absent | 1.00 (ref) | 1.00 (ref) | |||
Present | 11.10 (8.03–15.36) | < 0.001 | 4.45 (2.92–6.79) | < 0.001 | |
Lauren § | |||||
Intestinal | 1.00 (ref) | 1.00 (ref) | |||
Diffuse | 2.43 (1.72–3.41) | < 0.001 | 1.22 (0.60–2.48) | 0.585 | |
Mixed | 3.83 (2.79–5.25) | < 0.001 | 2.59 (1.51–4.42) | 0.001 | |
ELN | 1.02 (1.01–1.03) | 0.001 | 1.01 (1.00–1.03) | 0.119 | |