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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: CircLDLR acts as a sponge for miR-667-5p to regulate SIRT1 expression in non-alcoholic fatty liver disease

Fig. 1

OA/PA induces circLDLR downregulation and lipogenesis in hepatocytes. A ORO staining showed the lipid droplets in Hepa1-6 cells. *P < 0.05 vs. BSA group. B FISH showed the localization of circLDLR in Hepa1-6 cells. The nuclei were stained using DAPI solution. C The relative expression of circLDLR and LDLR in Hepa1-6 cells was measured via qRT-PCR. *P < 0.05, **P < 0.01 vs. BSA group. D The relative circLDLR expression and its linear LDLR with and without RNase R treatment by qRT-PCR in Hepa1-6 cells. ***P < 0.001 vs. RNase R- group. E The LDLR and circLDLR abundance in Actinomycin D-treated Hepa1-6 cells at specific time points was evaluated using qRT-PCR. **P < 0.01, ***P < 0.001 vs. circLDLR group

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Lipids in Health and Disease

ISSN: 1476-511X